Catalog No: OPPA02206 (Formerly GWB-FCDDEB)
Size:5UG
Price: $75.00
SKU
OPPA02206
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MGMT Protein (OPPA02206)

Datasheets/ManualsPrintable datasheet for OPPA02206
Product Info
Predicted Species ReactivityHuman
Product FormatThe MGMT solution contains 20mM Tris-HCl pH-7.5, 1mM DTT and 10% glycerol. Physical appearance: Sterile Filtered clear colorless solution.
HostE. Coli
::Product Introduction: MGMT is an enzyme that repairs O-6-methylguanine, a mutagenic DNA base damaged by endogenous and environmental alkylating agents and takes part in the cellular defense against the biological effects of O-6-methylguanine in DNA. MGMT repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. abnormal MGMT expression correlates with the prognosis in human solid cancers. MGMT decrease of expression is correlated with methylation. The human MGMT is a negative regulator of estrogen receptor-mediated transcription upon alkylation DNA damage. MGMT promoter hypermethylation plays an important role in the early steps of colorectal carcinogenesis. Abnormal promoter hypermethylation of MGMT gene is associated with oral squamous cell carcinomas.
Product Description: MGMT Human Recombinant fused to 20 amino acid His Tag at N-terminal produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 227 amino acids (1-207) and having a molecular mass of 23.8 kDa. The MGMT is purified by proprietary chromatographic techniques.
Reconstitution and StorageMGMT Recombinant Human although stable at 4C for 30 days, should be stored desiccated below -20C for periods greater than 30 days. Please avoid freeze-thaw cycles.
PurityGreater than 95.0% as determined by SDS-PAGE.
Peptide SequenceMGSSHHHHHH SSGLVPRGSH MDKDCEMKRT TLDSPLGKLE LSGCEQGLHE IKLLGKGTSA ADAVEVPAPA AVLGGPEPLM QCTAWLNAYF HQPEAIEEFP VPAFHHPVFQ QESFTRQVLW KLLKVVKFGE VISYQQLAAL AGNPKAARAV GGAMRGNPVP ILIPCHRVVC SSGAVGNYSG GLAVKEWLLA HEGHRLGKPG LGGSSGLAGA WLKGAGATSG SPPAGRN.
Gene SymbolMGMT
Alias SymbolsMethylated-DNA--protein-cysteine methyltransferase, 6-O-methylguanine-DNA methyltransferase, O-6-methylguanine-DNA-alkyltransferase, MGMT, MGMT Human, O-6-Methylguanine-DNA Methyltransferase Human Recombinant
NCBI Gene Id4255
Protein NameMethylated-DNA--protein-cysteine methyltransferase
Description of TargetRecombinant Human O-6-Methylguanine-DNA Methyltransferase
Uniprot IDP16455
Protein Size (# AA)Recombinant
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