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Catalog No: OPCD00818
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OPCD00818
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Datasheets/ManualsPrintable datasheet for MFN1 Recombinant Protein (OPCD00818)
Product Info
Predicted Species ReactivityHomo sapiens|Human
Product FormatFreeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
HostE.coli
ConjugationUnconjugated
ApplicationPositive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
Additional InformationEndotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
::Residues: Met1-Leu227
Reconstitution and Storage2°C to 8°C|-80°C
Concentration200 ug/mL (prior to lyoph)
Purity> 95%
SourceE.coli
TagN-terminal His Tag
Gene SymbolMFN1
Gene Full Namemitofusin 1
Alias Symbolsfzo homolog;hfzo1;hfzo2;mitochondrial transmembrane GTPase Fzo-1;mitochondrial transmembrane GTPase FZO-2;mitofusin-1;putative transmembrane GTPase;transmembrane GTPase MFN1.
NCBI Gene Id55669
Protein NameMitofusin-1
Description of TargetMitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:12475957, PubMed:12759376, PubMed:27920125, PubMed:28114303). Membrane clustering requires GTPase activity (PubMed:27920125). It may involve a major rearrangement of the coiled coil domains (PubMed:27920125, PubMed:28114303). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:12475957, PubMed:12759376). Overexpression induces the formation of mitochondrial networks (in vitro) (PubMed:12759376). Has low GTPase activity (PubMed:27920125, PubMed:28114303).
Uniprot IDQ8IWA4
Protein Accession #NP_284941.2
Nucleotide Accession #NM_033540.2
Protein Size (# AA)Met1~Leu227
Molecular Weight29kDa
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