Catalog No: OAAB06603
Size:400ul
Price: $463.00
SKU
OAAB06603
Availability: Domestic: within 1-2 week delivery | International: within 1-2 week delivery
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  • $55: Antibody & Protein in US
  • $55 + $25/Kit in US
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Datasheets/ManualsPrintable datasheet for OAAB06603
Product Info
Predicted Species ReactivityHuman, Mouse
Product FormatPurified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
ClonalityMonoclonal
Clone4AT44
IsotypeIgG1
HostMouse
ApplicationWB, IHC, IF
Additional InformationFunction: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1 Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells
::Cellular Location: Membrane; Single-pass type I membrane protein
Tissue Location: Expressed in normal hepatocytes as well as in epithelial cells lining the stomach, the small and the large intestine. Found also in basal keratinocytes of esophagus and skin. High levels are found in liver, gastrointestinal tract, thyroid and kidney. Also present in the brain
Reconstitution and StorageMaintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThis monoclonal antibody is generated from mice immunized with purified recombinant protein encoding the catalytic domain of human Met.
Predicted Homology Based on Immunogen SequenceHuman; Mouse
ConcentrationApproximately 0.5mg/ml. Actual concentration varies with each lot.
Application InfoIHC-P: 1:25
WB: 1:1000
IF: 1:100
WB: 1:100~500
IHC-P: 1:50~100
Intended UseMET/HGFR Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Gene SymbolMET
Alias SymbolsHGFR, AUTS9, RCCP2, c-Met, DFNB97
NCBI Gene Id4233
Protein NameHepatocyte growth factor receptor
Description of TargetPurified Mouse Monoclonal Antibody (Mab)
Uniprot IDP08581
Protein Accession #NP_000236.2
Molecular Weight155541 Da
  1. What is the species homology for "MET/HGFR Antibody (OAAB06603)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human, Mouse".

  2. How long will it take to receive "MET/HGFR Antibody (OAAB06603)"?

    This item is available "Domestic: within 1-2 week delivery | International: within 1-2 week delivery".

  3. What buffer format is "MET/HGFR Antibody (OAAB06603)" provided in?

    This item is provided in "Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "MET/HGFR Antibody (OAAB06603)"?

    This target may also be called "HGFR, AUTS9, RCCP2, c-Met, DFNB97" in publications.

  5. What is the shipping cost for "MET/HGFR Antibody (OAAB06603)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "MET/HGFR Antibody (OAAB06603)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "MET/HGFR Antibody (OAAB06603)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "155541 Da".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "MET/HGFR Antibody (OAAB06603)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "MET"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "MET"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "MET"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "MET"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "MET"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "MET"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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