MERTK Antibody (OACA07790)

Catalog No: OACA07790

Immunohistochemistry of paraffin-embedded human endometrial cancer at dilution 1:100

Immunohistochemistry of paraffin-embedded human tonsil tissue at dilution 1:100

Western blot
All lanes: MERTK antibody at 10ug/ml
Lane 1: mouse gonad tissue
Lane 2: mouse lung tissue
Lane 3: mouse kidney tissue
Secondary
Goat polyclonal to rabbit at 1/1,0000 dilution
Predicted band size: 110kDa
Observed band size: 110kDa

Western blot
All lanes: MERTK antibody at 10ug/ml
Lane 1: mouse gonad tissue
Lane 2: mouse lung tissue
Lane 3: mouse kidney tissue
Secondary
Goat polyclonal to rabbit at 1/1,0000 dilution
Predicted band size: 110kDa
Observed band size: 110kDa

Immunohistochemistry of paraffin-embedded human endometrial cancer at dilution 1:100

Immunohistochemistry of paraffin-embedded human tonsil tissue at dilution 1:100

Product Info

• Predicted Species Reactivity: Human|Mouse
• Product Format: Liquid
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Immunohistochemistry|Western blot
• Reconstitution and Storage: -20°C or -80°C
• Immunogen: Recombinant Human Tyrosine-protein kinase Mer protein (840-999AA)
• Purification: Affinity Purified
• Preservative: 0.02% sodium azide
• Formulation: PBS with, 50% glycerol, pH7.3.
• Reference: [1]"Mutations in MERTK, the human orthologue of the RCS rat retinal dystrophy gene, cause retinitis pigmentosa."Gal A., Li Y., Thompson D.A., Weir J., Orth U., Jacobson S.G., Apfelstedt-Sylla E., Vollrath D.Nat. Genet. 26:270-271(2000). [2]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. Wilson R.K. Nature 434:724-731(2005).

Target Info

• Gene Symbol: MERTK
• Gene Full Name: MER proto-oncogene, tyrosine kinase
• Alias Symbols: c-Eyk;c-mer;c-mer proto-oncogene tyrosine kinase;MER;MER receptor tyrosine kinase;proto-oncogene c-Mer;receptor tyrosine kinase MerTK;RP38;STK kinase;Tyro12;tyrosine-protein kinase Mer.
• NCBI Gene Id: 10461
• Protein Name: Tyrosine-protein kinase Mer
• Description of Target: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
• Uniprot ID: Q12866
• Protein Accession #: NP_006334
• Nucleotide Accession #: NM_006343