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MELK Antibody - middle region (ARP74061_P050)

100 ul
$289.00
In Stock
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Conjugation Options

ARP74061_P050-FITC Conjugated

ARP74061_P050-HRP Conjugated

ARP74061_P050-Biotin Conjugated

Tested Species Reactivity:
Human
Predicted Species Reactivity:
Human
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Clonality:
Polyclonal
Host:
Rabbit
Application:
WB
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Gene Symbol:
MELK
NCBI Gene Id:
9833
Swissprot Id:
Q14680-3
Alias Symbols:
MELK, KIAA0175,
Replacement Item:
This antibody may replace item sc-130816 from Santa Cruz Biotechnology.
Description of Target:
MELK is a serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. It acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. And it plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. It may also play a role in primitive hematopoiesis.
Protein Size (# AA):
457
Molecular Weight:
50kDa
Purification:
Affinity purified
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express MELK.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express MELK.
Immunogen:
The immunogen is a synthetic peptide directed towards the middle region of Human MELK
Peptide Sequence:
Synthetic peptide located within the following region: MEETPKRKGAKVFGSLERGLDKVITVLTRSKRKGSARDGPRRLKLHYNVT
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
UBC; YGR054W; Acaca; CSN1S1; MELK; MBP; LMNB1; BABAM1; ZNF622; SF3B1; EIF2S1; CDC5L; PPP1R8; HIST1H1B; CDC25B;
Blocking Peptide:
For anti-MELK (ARP74061_P050) antibody is Catalog # AAP74061
Datasheets/Manuals:
Printable datasheet for anti-MELK (ARP74061_P050) antibody
Target Reference:
N/A

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