MEF2C Antibody (OAAJ06373)

Catalog No: OAAJ06373

Size:100 uL

Western blot analysis of MEF2C expression in 3T3 cell extracts

Product Info

• Predicted Species Reactivity: Human, Mouse
• Product Format: Liquid PBS (pH 7.4), 150mM NaCl, 0.02% sodium azide and 50% glycerol
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: IHC-P, CHIP, ICC, IF, WB, IHC-F
  Subcellular Location: Nucleus
  Tissue Specificity: Expressed in brain and skeletal muscle
  Similarity: The beta domain, missing in a number of isoforms, is required for enhancement of transcriptional activity. Belongs to the MEF2 family.
• Reconstitution and Storage: Store at -20C. Stable for 12 months from date of receipt.
• Immunogen: A synthesized peptide derived from human MEF2C
• Purification: Immunogen affinity chromatography
• Concentration: 1 mg/mL
• Specificity: MEF2C Ab detects endogenous levels of total MEF2C.
• Application Info: IHC-P: 1:50~200
  IHC-F: 1:50~200
  ICC/IF: 1:100~500
  WB: 1:500~2000

Target Info

• Gene Symbol: MEF2C
• Alias Symbols: DEL5q14.3, C5DELq14.3
• NCBI Gene Id: 4208
• Protein Name: Myocyte-specific enhancer factor 2C
• Description of Target: Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture . Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.
• Uniprot ID: Q06413
• Protein Accession #: NP_001124477
• Nucleotide Accession #: NM_001131005
• Molecular Weight: 51 kDa