MEF2A Antibody - middle region (OAAB05850)

Catalog No: OAAB05850

Size:400UL

Western blot analysis of MEF2A Antibody (Center) in mouse brain tissue lysates (35ug/lane). MEF2A (arrow) was detected using the purified Pab.

MEF2A Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human tonsil tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the MEF2A Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.

Product Info

• Predicted Species Reactivity: Bovine|Human|Mouse|Porcine|Rat
• Product Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Clonality: Polyclonal
• Isotype: Rabbit Ig
• Host: Rabbit
• Application: IF,IHC-P,WB
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: This MEF2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 453-479 amino acids from the Central region of human MEF2A.
• Predicted Homology Based on Immunogen Sequence: Human; Mouse
• Concentration: Approximately 0.5mg/ml. Actual concentration varies with each lot.
• Application Info: WB: 1:1000
  IHC-P: 1:50~100
  IF: 1:10~50

Target Info

• Gene Symbol: MEF2A
• Alias Symbols: A430079H05Rik, ADCAD1, MADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A), mef2, myocyte-specific enhancer factor 2A, RSRFC4, RSRFC9, serum response factor-like protein 1.
• NCBI Gene Id: 100037273|17258|309957|407231|4205
• Protein Name: Myocyte-specific enhancer factor 2A|myocyte-specific enhancer factor 2A isoform 1 [Homo sapiens]|myocyte-specific enhancer factor 2A isoform 2 [Homo sapiens]|myocyte-specific enhancer factor 2A isoform 3 [Homo sapiens]|myocyte-specific enhancer factor 2A isoform 4 [Homo sapiens]
• Description of Target: Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter (By similarity).|Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter.
• Uniprot ID: A2ICN5|A2VDZ3|Q02078|Q2MJT0|Q60929
• Protein Accession #: https://www.ncbi.nlm.nih.gov/protein/NP_001124398.1,NP_001124399.1,NP_001124400.1,NP_001165365.1,NP_005578.2
• Molecular Weight: 54811