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MECP2 Antibody (OADC00178)

Catalog#: OADC00178
Domestic: within 1 week delivery | International: 1 week
More Information
Predicted Species ReactivityHuman
Product FormatLiquid. Provided in PBS containing 0.05% azide and 0.05% ProClin 300.
ApplicationCHIP, WB
Reconstitution and StorageStore at -20C. Avoid repeated freeze/thaw cycles.
Replacement ItemThis antibody may replace item sc-137070 from Santa Cruz Biotechnology.
PurificationAffinity purified
Concentration1.2 mg/mL
Datasheets/ManualsPrintable datasheet for anti-MECP2 (OADC00178) antibody
Preservative0.05% Sodium Azide and 0.05% ProClin 300.
SpecificityPolyclonal antibody raised in rabbit against MeCP2 (Methyl-CpG-binding domain protein 2), using a KLH-conjugated synthetic peptide containing a sequence from the C-terminal part of the protein.
Application InfoCHIP: 5 ug/CHIP
ELISA: 1:1,000
Western Blotting: 1:1,000
Gene SymbolMECP2
Official Gene Full Namemethyl-CpG binding protein 2
Alias SymbolsRS, RTS, RTT, PPMX, MRX16, MRX79, MRXSL, AUTSX3, MRXS13
NCBI Gene Id4204;
Protein Namemethyl-CpG-binding protein 2
Description of TargetDNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. Alternative splicing results in multiple transcript variants encoding different isoforms.
Swissprot IdP51608
Protein Accession #NP_001104262.1
Nucleotide Accession #NM_001110792.1
Tissue ToolFind tissues and cell lines supported by DNA array analysis to express MECP2.
RNA SeqFind tissues and cell lines supported by RNA-seq analysis to express MECP2.
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