MECP2 Antibody (OACA07153)

Catalog No: OACA07153

Immunohistochemistry of paraffin-embedded human tonsil at dilution 1:100

Immunohistochemistry of paraffin-embedded human tonsil at dilution 1:100

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Immunohistochemistry
• Reconstitution and Storage: -20°C or -80°C
• Immunogen: Recombinant Human Methyl-CpG-binding protein 2 protein (1-280AA)
• Purification: Affinity Purified
• Preservative: 0.02% sodium azide
• Formulation: PBS with, 50% glycerol, pH7.3.
• Reference: [1]"Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation."Nan X., Hou J., Maclean A., Nasir J., Lafuente M.J., Shu X., Kriaucionis S., Bird A.Proc. Natl. Acad. Sci. U.S.A. 104:2709-2714(2007). [2]"A novel familial MECP2 mutation in a young boy: clinical and molecular findings."Ventura P., Galluzzi R., Bacca S.M., Giorda R., Massagli A. Neurology 67:867-868(2006). [3]"Duplication of the MECP2 region is a frequent cause of severe mental retardation and progressive neurological symptoms in males."Van Esch H., Bauters M., Ignatius J., Jansen M., Raynaud M., Hollanders K., Lugtenberg D., Bienvenu T., Jensen L.R., Gecz J., Moraine C., Marynen P., Fryns J.-P., Froyen G.Am. J. Hum. Genet. 77:442-453(2005).

Target Info

• Gene Symbol: MECP2
• Gene Full Name: methyl-CpG binding protein 2
• Alias Symbols: AUTSX3;meCp-2 protein;methyl-CpG-binding protein 2;MRX16;MRX79;MRXS13;MRXSL;PPMX;RS;RTS;RTT.
• NCBI Gene Id: 4204
• Protein Name: Methyl-CpG-binding protein 2
• Description of Target: Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC).
• Uniprot ID: P51608
• Protein Accession #: NP_001104262
• Nucleotide Accession #: NM_001110792