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MECP2 Antibody - N-terminal region (ARP43584_T100)

100 ul
$229.00
In Stock
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Conjugation Options

ARP43584_T100-FITC Conjugated

ARP43584_T100-HRP Conjugated

ARP43584_T100-Biotin Conjugated

Gene Symbol:
MECP2
Official Gene Full Name:
Methyl CpG binding protein 2 (Rett syndrome)
NCBI Gene Id:
4204
Protein Name:
Methyl-CpG-binding protein 2
Swissprot Id:
P51608
Protein Accession #:
NP_004983
Nucleotide Accession #:
NM_004992
Alias Symbols:
AUTSX3, DKFZp686A24160, MRX16, MRX79, PPMX, RTS, RTT, RS, MRXSL, MRXS13
Replacement Item:
This antibody may replace item sc-137070 from Santa Cruz Biotechnology.
Description of Target:
Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of some cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of some cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.
Protein Size (# AA):
486
Molecular Weight:
52kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Protein A purified
Application:
WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express MECP2.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express MECP2.
Immunogen:
The immunogen is a synthetic peptide directed towards the N terminal region of human MECP2
Predicted Species Reactivity:
Cow, Dog, Horse, Human, Mouse, Pig, Rat
Tested Species Reactivity:
Human
Predicted Homology Based on Immunogen Sequence:
Cow: 91%; Dog: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 93%; Rat: 93%
Complete computational species homology data:
Anti-MECP2 (ARP43584_T100)
Peptide Sequence:
Synthetic peptide located within the following region: MVAGMLGLREEKSEDQDLQGLKEKPLKFKKVKKDKKEDKEGKHEPLQPSA
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
UBC; HECW2; Hipk2; SOX18; WHSC1; HPDL; XPC; CAT; HIST2H3C; HIST1H4F; HIST2H2BE; HIST2H2AC; CBX3; CBX1; SMC3; YBX1; SIN3A; CBX5; ELAVL1; SUMO2; PPARG; YY1; TERF2; SMARCA2; SOX2; SP1; SP3; LOC407840; CDKL5; PRPF40A; SMARCB1; NCOR1; SKI; HMGB1; SPI1; LBR; RB
Blocking Peptide:
For anti-MECP2 (ARP43584_T100) antibody is Catalog # AAP43584 (Previous Catalog # AAPS13611)
Datasheets/Manuals:
Printable datasheet for anti-MECP2 (ARP43584_T100) antibody
Target Reference:
Robertson,L., (2006) Am. J. Med. Genet. B Neuropsychiatr. Genet. 141 (2), 177-183
Publications:

Jungwirth, M., Dear, M. L., Brown, P., Holbrook, K. & Goodchild, R. Relative tissue expression of homologous torsinB correlates with the neuronal specific importance of DYT1 dystonia-associated torsinA. Hum. Mol. Genet. 19, 888-900 (2010). WB, Cow, Dog, Horse, Human, Mouse, Pig, Rat 20034025

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