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MDM2 Antibody - middle region (ARP88009_P050)

100 ul
$289.00
In Stock
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Tested Species Reactivity:
Human
Predicted Species Reactivity:
Human
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Clonality:
Polyclonal
Host:
Rabbit
Application:
WB
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Gene Symbol:
MDM2
Official Gene Full Name:
MDM2 proto-oncogene
NCBI Gene Id:
4193
Protein Name:
E3 ubiquitin-protein ligase Mdm2
Swissprot Id:
Q00987-8
Protein Accession #:
NP_001138811.1
Nucleotide Accession #:
NM_001145339.2
Alias Symbols:
HDMX, hdm2, ACTFS
Description of Target:
This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.
Protein Size (# AA):
430
Molecular Weight:
47 kDa
Purification:
Affinity purified
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express MDM2.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express MDM2.
Immunogen:
The immunogen is a synthetic peptide directed towards the middle region of human MDM2
Peptide Sequence:
Synthetic peptide located within the following region: KSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGD
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Blocking Peptide:
For anti-MDM2 (ARP88009_P050) antibody is Catalog # AAP88009
Datasheets/Manuals:
Printable datasheet for anti-MDM2 (ARP88009_P050) antibody

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