MCTS1 Antibody - N-terminal region (ARP40751_P050)

Catalog No: ARP40751_P050

WB Suggested Anti-MCTS1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: COLO205 cell lysateMCTS1 is supported by BioGPS gene expression data to be expressed in COLO205

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Rabbit, Zebrafish
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human MCTS1
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 93%; Zebrafish: 86%
• Peptide Sequence: Synthetic peptide located within the following region: MFKKFDEKENVSNCIQLKTSVIKGIKNQLIEQFPGIEPWLNQIMPKKDPV
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-MCTS1 (ARP40751_P050) antibody is Catalog # AAP40751 (Previous Catalog # AAPY01003)
• Sample Type Confirmation:

  MCTS1 is supported by BioGPS gene expression data to be expressed in COLO205

• Reference: Shi,B., (2003) J. Cell. Biochem. 90 (1), 68-79

Target Info

• Gene Symbol: MCTS1
• Gene Full Name: Malignant T cell amplified sequence 1
• Alias Symbols: MCT1, MCT-1
• NCBI Gene Id: 28985
• Protein Name: Malignant T-cell-amplified sequence 1
• Description of Target: MCTS1 is an anti-oncogene that play a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constituvely expressed, MCTS1 increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. MCTS1 plays a role as translation enhancer; and recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile; MCTS1 up-regulates protein levels of BCL2L2, TFDP1, MRE11A, CCND1 and E2F1, while mRNA levels remains constant. MCTS1 hyperactivates DNA damage signaling pathway; increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. MCTS1 increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiples chromosomal fusions when over-expressed in gamma-irradiated cells. MCTS1 may play a role in promoting lymphoid tumor development: lymphoid cell lines over-expressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. MCTS1 may contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. MCTS1 is involved in the process of proteosome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell; MCTS1 positively regulates phosphorylation of MAPK1 and MAPK3.
• Uniprot ID: Q9ULC4
• Protein Accession #: NP_054779
• Nucleotide Accession #: NM_014060
• Protein Size (# AA): 181
• Molecular Weight: 20kDa
• Protein Interactions: ASB6; IPO9; OGFOD1; STK26; UBXN1; ISOC1; TWF2; PROSC; TUBB4B; PDCD6IP; NAE1; USP5; YWHAE; UBA1; PTMA; TWF1; MYO1E; IPO5; HMGB3; HDGF; DHX15; ATIC; UBC; DENR; SUMO1;