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MCM8 Antibody - C-terminal region (ARP36668_P050)

100 ul

Regular Price: $289.00

Special Price: $229.00

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Conjugation Options

ARP36668_P050-FITC Conjugated

ARP36668_P050-HRP Conjugated

ARP36668_P050-Biotin Conjugated

Tested Species Reactivity:
Human
Predicted Species Reactivity:
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Clonality:
Polyclonal
Host:
Rabbit
Application:
IHC, WB
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Replacement Item:
This antibody may replace item sc-47117 from Santa Cruz Biotechnology.
Immunogen:
The immunogen is a synthetic peptide directed towards the C terminal region of human MCM8
Purification:
Affinity Purified
Predicted Homology Based on Immunogen Sequence:
Cow: 100%; Dog: 93%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 86%
Complete computational species homology data:
Anti-MCM8 (ARP36668_P050)
Peptide Sequence:
Synthetic peptide located within the following region: IRLTEARARLELREEATKEDAEDIVEIMKYSMLGTYSDEFGNLDFERSQH
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Blocking Peptide:
For anti-MCM8 (ARP36668_P050) antibody is Catalog # AAP36668 (Previous Catalog # AAPS06309)
Datasheets/Manuals:
Printable datasheet for anti-MCM8 (ARP36668_P050) antibody
Target Reference:
Clarke,C.A. Biochem. J. 388 (PT 2), 705-712 (2005)
Publications:

Ono, A. et al. Overexpression of heat shock protein 27 in squamous cell carcinoma of the uterine cervix: a proteomic analysis using archival formalin-fixed, paraffin-embedded tissues. Hum. Pathol. 40, 41-9 (2009). IHC, WB, Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish 18755499

Gene Symbol:
MCM8
Official Gene Full Name:
Minichromosome maintenance complex component 8
Alias Symbols:
C20orf154, MGC119522, MGC119523, MGC12866, MGC4816, REC, dJ967N21.5
NCBI Gene Id:
84515
Protein Name:
DNA helicase MCM8
Description of Target:
MCM8 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central domain that is conserved among the MCM proteins. This protein has been shown to co-immunoprecipitate with MCM4, 6 and 7, which suggests that it may interact with other MCM proteins and play a role in DNA replication. Alternatively spliced transcript variants encoding distinct isoforms have been described.The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central domain that is conserved among the MCM proteins. This protein has been shown to co-immunoprecipitate with MCM4, 6 and 7, which suggests that it may interact with other MCM proteins and play a role in DNA replication. Alternatively spliced transcript variants encoding distinct isoforms have been described.
Swissprot Id:
Q9UJA3
Protein Accession #:
NP_115874
Nucleotide Accession #:
NM_032485
Protein Size (# AA):
840
Molecular Weight:
94kDa
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express MCM8.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express MCM8.
Protein Interactions:
MCMBP; MCM4; MCM6; MCM7; ORC2; CDC6;

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