- Tested Species Reactivity:
- Human
- Predicted Species Reactivity:
- Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
- Product Format:
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
- Clonality:
- Polyclonal
- Host:
- Rabbit
- Application:
- WB
- Reconstitution and Storage:
- For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
- Gene Symbol:
- MCM7
- Official Gene Full Name:
- minichromosome maintenance complex component 7
- NCBI Gene Id:
- 4176
- Protein Name:
- DNA replication licensing factor MCM7
- Swissprot Id:
- P33993-2
- Protein Accession #:
- NP_877577
- Nucleotide Accession #:
- NM_182776
- Alias Symbols:
- CDC47, MCM2, P1.1-MCM3, P1CDC47, P85MCM, PNAS146
- Replacement Item:
- This antibody may replace item sc-173959 from Santa Cruz Biotechnology.
- Description of Target:
- MCM7 encodes a protein that is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB.
- Protein Size (# AA):
- 389
- Molecular Weight:
- 42kDa
- Purification:
- Affinity Purified
- Tissue Tool:
- Find tissues and cell lines supported by DNA array analysis to express MCM7.
- RNA Seq:
- Find tissues and cell lines supported by RNA-seq analysis to express MCM7.
- Immunogen:
- The immunogen is a synthetic peptide directed towards the N-terminal region of Human MCM7
- Predicted Homology Based on Immunogen Sequence:
- Cow: 86%; Dog: 86%; Guinea Pig: 93%; Horse: 79%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 100%; Zebrafish: 93%
- Peptide Sequence:
- Synthetic peptide located within the following region: KYGNQLVRLAHREQVALYVDLDDVAEDDPELVDSICENARRYAKLFADAV
- Concentration:
- Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
- Protein Interactions:
- AK8; MIPOL1; C8orf34; USHBP1; MCMBP; CCDC102B; TRIM54; MBIP; UBQLN1; TRIM27; NAB2; KIFC3; GOLGA2; PNMA1; UBC; SP2; HAUS2; CEP250; CEP57; SUMO2; SUMO3; PCNA; STAU1; SUZ12; RNF2; MCM4; MCM2; HSP90AB1; PRMT1; PRRC1; CLUH; TOMM34; TRIM16; HYOU1; BAG3; MIB1; P
- Blocking Peptide:
- For anti-MCM7 (ARP36693_P050) antibody is Catalog # AAP36693
- Datasheets/Manuals:
- Printable datasheet for anti-MCM7 (ARP36693_P050) antibody
Product Reviews
- Protocol:
- Tips Information:
See our General FAQ page.
