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MCM3 Antibody (OACA02425)

100 ul
$315.00
In Stock
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Predicted Species Reactivity:
Human
Product Format:
Liquid
Clonality:
Polyclonal
Isotype:
IgG
Host:
Rabbit
Application:
WB, IHC, CHIP
Reconstitution and Storage:
Store at 4C for up to one month. For long term storage, aliquot and store at -20C or -80C. Avoid freeze thaw cycles.
Replacement Item:
This antibody may replace item sc-173130, HPA004789
Immunogen:
Recombinant human DNA replication licensing factor MCM3 protein (1-295aa)
Purification:
Antigen Affinity Purified
Predicted Homology Based on Immunogen Sequence:
Human
Datasheets/Manuals:
Printable datasheet for anti-MCM3 (OACA02425) antibody
Specificity:
Human
Formulation:
Provided in PBS, pH 7.3, 50% Glycerol, 0.02% Sodium Azide
Application Data:
WB:1:200-1000, IHC:1:20-1:200
Target Reference:
[1] A role for the Ankyrin repeat containing protein Ankrd17 in Nod1- and Nod2-mediated inflammatory responses. Menning M., Kufer T.A.FEBS Lett. 587:2137-2142 (2013).
[2] N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454 (2012).
[3] Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.Mol. Cell. Proteomics 11:M111.015131-M111.015131 (2012).
Gene Symbol:
MCM3
Official Gene Full Name:
minichromosome maintenance complex component 3
Alias Symbols:
HCC5, P1.h, RLFB, P1-MCM3
NCBI Gene Id:
4172
Protein Name:
DNA replication licensing factor MCM3
Description of Target:
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Two transcript variants encoding different isoforms have been found for this gene.
Swissprot Id:
P25205
Protein Accession #:
NP_001257401.1
Nucleotide Accession #:
NM_001270472.1
Protein Size (# AA):
808
Molecular Weight:
91 kDa
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express MCM3.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express MCM3.

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