Size:100 ul
$229.00
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ARP36647_T100
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Conjugation Options

ARP36647_T100-FITC Conjugated

ARP36647_T100-HRP Conjugated

ARP36647_T100-Biotin Conjugated

MCM2 Antibody - N-terminal region (ARP36647_T100)

Rating:
80% of 100
Catalog#: ARP36647_T100
Domestic: within 1-2 days delivery | International: 1-2 days
More Information
Tested Species Reactivity Human, Mouse
Predicted Species Reactivity Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Clonality Polyclonal
Host Rabbit
Application WB
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Replacement Item This antibody may replace item sc-10771 from Santa Cruz Biotechnology.
Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human MCM2
Purification Protein A purified
Predicted Homology Based on Immunogen Sequence Cow: 100%; Dog: 93%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 93%; Pig: 100%; Rabbit: 100%; Rat: 93%
Complete computational species homology data Anti-MCM2 (ARP36647_T100)
Peptide Sequence Synthetic peptide located within the following region: PGRSSRRTDALTSSPGRDLPPFEDESEGLLGTEGPLEEEEDGEELIGDGM
Concentration Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Blocking Peptide For anti-MCM2 (ARP36647_T100) antibody is Catalog # AAP36647 (Previous Catalog # AAPP07904)
Datasheets/Manuals Printable datasheet for anti-MCM2 (ARP36647_T100) antibody
Sample Type Confirmation

MCM2 is supported by BioGPS gene expression data to be expressed in Jurkat

Target Reference Yu,Z., et al., (2004) J. Mol. Biol. 340 (5), 1197-1206
Publications

Rizwani, W., Alexandrow, M. & Chellappan, S. Prohibitin physically interacts with MCM proteins and inhibits mammalian DNA replication. Cell Cycle 8, 1621-9 (2009). WB, Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat 19377303

Gene Symbol MCM2
Official Gene Full Name Minichromosome maintenance complex component 2
Alias Symbols BM28, CCNL1, CDCL1, cdc19, D3S3194, MITOTIN
NCBI Gene Id 4171
Protein Name DNA replication licensing factor MCM2
Description of Target The protein encoded by MCM2 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7.
Swissprot Id P49736
Protein Accession # NP_004517
Nucleotide Accession # NM_004526
Protein Size (# AA) 904
Molecular Weight 99kDa
Tissue Tool Find tissues and cell lines supported by DNA array analysis to express MCM2.
RNA Seq Find tissues and cell lines supported by RNA-seq analysis to express MCM2.
Protein Interactions HUWE1; MCM6; CHFR; SUMO2; MCMBP; UBC; SUMO1; MDM2; MCM7; MCM4; HSP90AB1; ACLY; PRRC1; HYOU1; CAP1; NCL; POLA1; TONSL; SNF8; ELL; TCEA1; POLR2A; CDK6; CDK4; CDC6; MCM10; ORC6; CCNB2; VCAM1; P2RX4; ORC5; ORC2; MCM5; MCM3; ITGA4; FN1; CSNK2A1; CDKN2A; DBF4;
  1. What is the species homology for "MCM2 Antibody - N-terminal region (ARP36647_T100)"?

    The tested species reactivity for this item is "Human, Mouse". This antibody is predicted to have homology to "Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat".

  2. How long will it take to receive "MCM2 Antibody - N-terminal region (ARP36647_T100)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "MCM2 Antibody - N-terminal region (ARP36647_T100)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "MCM2 Antibody - N-terminal region (ARP36647_T100)"?

    This target may also be called "BM28, CCNL1, CDCL1, cdc19, D3S3194, MITOTIN" in publications.

  5. What is the shipping cost for "MCM2 Antibody - N-terminal region (ARP36647_T100)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "MCM2 Antibody - N-terminal region (ARP36647_T100)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "MCM2 Antibody - N-terminal region (ARP36647_T100)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "99kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "MCM2 Antibody - N-terminal region (ARP36647_T100)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data tab on the product page.

  10. What are positive controls for "MCM2"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "MCM2"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "MCM2"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "MCM2"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "MCM2"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "MCM2"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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