Size:100 ul
$229.00
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SKU
ARP36647_T100
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Conjugation Options

ARP36647_T100-FITC Conjugated

ARP36647_T100-HRP Conjugated

ARP36647_T100-Biotin Conjugated

MCM2 Antibody - N-terminal region (ARP36647_T100)

Rating:
80% of 100
Catalog#: ARP36647_T100
Domestic: within 1-2 days delivery International: 1-2 days
More Information
Tested Species Reactivity Human, Mouse
Predicted Species Reactivity Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Clonality Polyclonal
Host Rabbit
Application WB
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Replacement Item This antibody may replace item sc-10771 from Santa Cruz Biotechnology.
Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human MCM2
Purification Protein A purified
Predicted Homology Based on Immunogen Sequence Cow: 100%; Dog: 93%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 93%; Pig: 100%; Rabbit: 100%; Rat: 93%
Complete computational species homology data Anti-MCM2 (ARP36647_T100)
Peptide Sequence Synthetic peptide located within the following region: PGRSSRRTDALTSSPGRDLPPFEDESEGLLGTEGPLEEEEDGEELIGDGM
Concentration Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Blocking Peptide For anti-MCM2 (ARP36647_T100) antibody is Catalog # AAP36647 (Previous Catalog # AAPP07904)
Datasheets/Manuals Printable datasheet for anti-MCM2 (ARP36647_T100) antibody
Sample Type Confirmation

MCM2 is supported by BioGPS gene expression data to be expressed in Jurkat

Target Reference Yu,Z., et al., (2004) J. Mol. Biol. 340 (5), 1197-1206
Publications

Rizwani, W., Alexandrow, M. & Chellappan, S. Prohibitin physically interacts with MCM proteins and inhibits mammalian DNA replication. Cell Cycle 8, 1621-9 (2009). WB, Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat 19377303

Gene Symbol MCM2
Official Gene Full Name Minichromosome maintenance complex component 2
Alias Symbols BM28, CCNL1, CDCL1, cdc19, D3S3194, MITOTIN
NCBI Gene Id 4171
Protein Name DNA replication licensing factor MCM2
Description of Target The protein encoded by MCM2 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7.
Swissprot Id P49736
Protein Accession # NP_004517
Nucleotide Accession # NM_004526
Protein Size (# AA) 904
Molecular Weight 99kDa
Tissue Tool Find tissues and cell lines supported by DNA array analysis to express MCM2.
RNA Seq Find tissues and cell lines supported by RNA-seq analysis to express MCM2.
Protein Interactions HUWE1; MCM6; CHFR; SUMO2; MCMBP; UBC; SUMO1; MDM2; MCM7; MCM4; HSP90AB1; ACLY; PRRC1; HYOU1; CAP1; NCL; POLA1; TONSL; SNF8; ELL; TCEA1; POLR2A; CDK6; CDK4; CDC6; MCM10; ORC6; CCNB2; VCAM1; P2RX4; ORC5; ORC2; MCM5; MCM3; ITGA4; FN1; CSNK2A1; CDKN2A; DBF4;
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