Size:100 ug
$269.00
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OABB00147
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MBP Polyclonal Antibody (OABB00147)

Catalog#: OABB00147
Domestic: within 1 week delivery | International: 1 week
This product is Genway GWB-BBP071
More Information
Predicted Species Reactivity Human, Mouse, Rat
Product Format Lyophilized Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3
Clonality Polyclonal
Isotype Rabbit IgG
Host Rabbit
Application WB, IHC-P, IF
Additional Information Tissue Specificity: MBP isoforms are found in both the central and the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from the immune system.
Subcellular Localization: Myelin membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic side of myelin.
Reconstitution and Storage 0.2ml of distilled water will yield a concentration of 500 ug/ml. Store at -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.
Replacement Item This antibody may replace item sc-17908, HPA002027
Immunogen A synthetic peptide corresponding to a sequence at the C-terminus of human Myelin Basic Protein (182-197aa KLGGRDSRSGSPMARR), identical to the related rat and mouse sequences.
Purification Immunogen affinity purified
Datasheets/Manuals Printable datasheet for OABB00147
Specificity No cross reactivity with other proteins.
Dilution Optimal dilutions should be determined by end user.
Application Info WB: 0.1-0.5 ug/mL. Tested Species: Hu, Ms, Rat
IHC-P: 0.5-1 ug/mL. Tested Species: Ms, Rat. Predicted Species: Hu. Antigen retrieval is by heat, where boiling the paraffin sections in 10 mM citrate buffer (pH 6.0) for 20 mins is required for the staining of formalin/paraffin sections.
IF: 2 ug/mL. Tested Species: Ms, Rat. Predicted Species: Hu
Target Reference 1. Marty MC, Alliot F, Rutin J, Fritz R, Trisler D, Pessac B.The myelin basic protein gene is expressed
in differentiated blood cell lineages and in hemopoietic progenitors. Proc Natl Acad Sci U S A. 2002
Jun 25; 99(13):8856-61.
2. Streicher R, Stoffel W.The organization of the human myelin basic protein gene. Comparison with
the mouse gene. Biol Chem Hoppe Seyler. 1989 May; 370(5):503-10.
3. McLaurin JA, Hafler DA, Antel JP.Reactivity of normal T-cell lines to MBP isolated from normal and
multiple sclerosis white matter. J Neurol Sci. 1995 Feb; 128(2):205-11.
4. Iester A, Vignola S, Callegarini L, Gimelli G, Alpigiani MG. [18q syndrome with deficiency of myelin
basic protein (MBP)] Pediatr Med Chir. 1996 Mar-Apr; 18(2):201-5.
5. Tranquill LR, Skinner E, Campagnoni C, Vergelli M, Hemmer B, Muraro P, Martin R, McFarland HF,
Campagnoni AT, Voskuhl RR. Human T lymphocytes specific for the immunodominant 83-99
epitope of myelin basic protein: recognition of golli MBP HOG 7. J Neurosci Res. 1996 Sep 15;
45(6):820-8.
Publications

Li, H; Ruberu, K; Karl, T; Garner, B; Cerebral Apolipoprotein-D Is Hypoglycosylated Compared to Peripheral Tissues and Is Variably Expressed in Mouse and Human Brain Regions. 11, e0148238 (2016). WB, IHC-P, Human, Mouse, Rat 26829325

Gene Symbol MBL2
Alias Symbols MBL, MBP, MBP1, MBPD, MBL2D, MBP-C, COLEC1, HSMBPC,
NCBI Gene Id 4153
Protein Name Mannose-binding protein C
Description of Target Myelin basic protein (MBP) is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the central nervous system and the peripheral nervous system, respectively. It is most abundant in hemopoietic system and contains seven exons distributed over 32-34 kb. MBP isolated from MS brain may differ in charge microheterogeneity which would affect antigenic determinants. MBP is mapped to chromosome 18q22-23. Failure in this gene expression would be correlated in the central white matter with extrapyramidal system degeneration signs. Moreover, it is a candidate autoantigen in the disease multiple sclerosis.
Swissprot Id P11226
Molecular Weight 33 kDa
Tissue Tool Find tissues and cell lines supported by DNA array analysis to express MBL2.
RNA Seq Find tissues and cell lines supported by RNA-seq analysis to express MBL2.
  1. What is the species homology for "MBP Polyclonal Antibody (OABB00147)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human, Mouse, Rat".

  2. How long will it take to receive "MBP Polyclonal Antibody (OABB00147)"?

    This item is available "Domestic: within 1 week delivery | International: 1 week".

  3. What buffer format is "MBP Polyclonal Antibody (OABB00147)" provided in?

    This item is provided in "Lyophilized Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "MBP Polyclonal Antibody (OABB00147)"?

    This target may also be called "MBL, MBP, MBP1, MBPD, MBL2D, MBP-C, COLEC1, HSMBPC, " in publications.

  5. What is the shipping cost for "MBP Polyclonal Antibody (OABB00147)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "MBP Polyclonal Antibody (OABB00147)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "MBP Polyclonal Antibody (OABB00147)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "33 kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "MBP Polyclonal Antibody (OABB00147)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data tab on the product page.

  10. What are positive controls for "MBL2"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "MBL2"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "MBL2"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "MBL2"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "MBL2"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "MBL2"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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