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Catalog No: ARP34797_P050-FITC
Size:100ul
Price: $434.00
SKU
ARP34797_P050-FITC
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MBD4 Antibody - middle region : FITC (ARP34797_P050-FITC)

Datasheets/ManualsPrintable datasheet for anti-MBD4 (ARP34797_P050-FITC) antibody
Product Info
Predicted Species ReactivityHuman, Guinea Pig
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer.
ClonalityPolyclonal
HostRabbit
ConjugationFITC: Fluorescein Isothiocyanate
ApplicationWB, CHIP
Reconstitution and StorageAll conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
ImmunogenThe immunogen is a synthetic peptide directed towards the middle region of human MBD4
PurificationAffinity Purified
Predicted Homology Based on Immunogen SequenceGuinea Pig: 83%; Human: 100%
Peptide SequenceSynthetic peptide located within the following region: CSEQKTSGIINKFCSAKDSEHNEKYEDTFLESEEIGTKVEVVERKEHLHT
Concentration0.5 mg/ml
Blocking PeptideFor anti-MBD4 (ARP34797_P050-FITC) antibody is Catalog # AAP34797 (Previous Catalog # AAPP05991)
Sample Type Confirmation

MBD4 is strongly supported by BioGPS gene expression data to be expressed in HeLa

ReferenceMiao,R., (er) Lung Cancer (2008) In press
Gene SymbolMBD4
Gene Full NameMethyl-CpG binding domain protein 4
Alias SymbolsMED1
NCBI Gene Id8930
Protein NameMethyl-CpG-binding domain protein 4
Description of TargetMBD4 is involved with DNA methylation. DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD3 comprise a family of nuclear proteins related by??he presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MBD4 may function to mediate the biological consequences of the methylation signal. In addition, MBD4 has protein sequence similarity to bacterial DNA repair enzymes and thus may have some function in DNA repair. Further, MBD4 gene mutations are detected in tumors with primary microsatellite-instability (MSI), a form of genomic instability associated with defective DNA mismatch repair, and MBD4 gene meets 4 of 5 criteria of a bona fide MIS target gene.DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MBD4 may function to mediate the biological consequences of the methylation signal. In addition, MBD4 has protein sequence similarity to bacterial DNA repair enzymes and thus may have some function in DNA repair. Further, MBD4 gene mutations are detected in tumors with primary microsatellite-instability (MSI), a form of genomic instability associated with defective DNA mismatch repair, and MBD4 gene meets 4 of 5 criteria of a bona fide MIS target gene. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Uniprot IDO95243
Protein Accession #NP_003916
Nucleotide Accession #NM_003925
Protein Size (# AA)580
Molecular Weight66kDa
Protein InteractionsKDM1A; SUV39H1; HTT; FAS; SUMO2; UBC; CDCA2; Trim27; FADD; MLH1; CSNK2B; DNMT3B; SIN3A; HDAC1;
  1. What is the species homology for "MBD4 Antibody - middle region : FITC (ARP34797_P050-FITC)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human, Guinea Pig".

  2. How long will it take to receive "MBD4 Antibody - middle region : FITC (ARP34797_P050-FITC)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "MBD4 Antibody - middle region : FITC (ARP34797_P050-FITC)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "MBD4 Antibody - middle region : FITC (ARP34797_P050-FITC)"?

    This target may also be called "MED1" in publications.

  5. What is the shipping cost for "MBD4 Antibody - middle region : FITC (ARP34797_P050-FITC)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "MBD4 Antibody - middle region : FITC (ARP34797_P050-FITC)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "MBD4 Antibody - middle region : FITC (ARP34797_P050-FITC)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "66kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "MBD4 Antibody - middle region : FITC (ARP34797_P050-FITC)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "MBD4"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "MBD4"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "MBD4"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "MBD4"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "MBD4"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "MBD4"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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