MaxiK Alpha Antibody (OAAF05841)

Catalog No: OAAF05841

Size:100 ug

Western blot analyzes of MaxiK? antibody in extracts from HeLa cells.

Immunohistochemistry analyzes of MaxiK? antibody in paraffin-embedded human brain tissue.

Product Info

• Predicted Species Reactivity: Human|Mouse|Rat
• Clonality: Polyclonal
• Host: Rabbit
• Application: Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry|Immunohistochemistry-Paraffin|Western blot
• Reconstitution and Storage: -20°C
• Immunogen: The antiserum was produced against synthesized peptide derived from human MaxiKalpha.
• Purification: The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.
• Concentration: 1 mg/ml
• Specificity: MaxiKalpha antibody detects endogenous levels of MaxiKalpha.
• Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Application Info: WB: 1:500 - 1:1000
  IHC: 1:50 - 1:100
  ELISA: 1:10000

Target Info

• Gene Symbol: KCNMA1
• Gene Full Name: potassium calcium-activated channel subfamily M alpha 1
• Alias Symbols: bA205K10.1;big potassium channel alpha subunit;BK channel;BK channel alpha subunit;BKCA alpha;BKCA alpha subunit;BKTM;CADEDS;Calcium-activated potassium channel subunit alpha-1;calcium-activated potassium channel, subfamily M subunit alpha-1;hSlo;IEG16;k(VCA)alpha;KCa1.1;LIWAS;Maxi K channel;MaxiK;maxi-K channel HSLO;mSLO1;PNKD3;potassium channel, calcium activated large conductance subfamily M alpha, member 1;potassium large conductance calcium-activated channel, subfamily M, alpha member 1;SAKCA;SLO;slo homolog;SLO1;SLO-ALPHA;slowpoke homolog;stretch-activated Kca channel.
• NCBI Gene Id: 3778
• Protein Name: Calcium-activated potassium channel subunit alpha-1
• Description of Target: Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX).
• Uniprot ID: Q12791
• Molecular Weight: 137 kDa