MASP1 Recombinant Protein (OPCD05138)

Catalog No: OPCD05138

MASP1 Recombinant Protein (OPCD05138) using SDS-PAGE

MASP1 Recombinant Protein (OPCD05138) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: His20-Ala447
  Subcellular Location: Secreted
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: MASP1
• Gene Full Name: MBL associated serine protease 1
• Alias Symbols: 3MC1;C4/C2 activating component of Ra-reactive factor;complement factor MASP-3;complement-activating component of Ra-reactive factor;CRARF;CRARF1;mannan binding lectin serine peptidase 1;mannan-binding lectin serine protease 1;mannose-associated serine protease 1;mannose-binding lectin-associated serine protease 1;mannose-binding protein-associated serine protease;MAP1;MAP-1;MAp44;MASP;MASP3;MASP-3;PRSS5;Ra-reactive factor serine protease p100;RaRF;serine protease 5.
• NCBI Gene Id: 5648
• Protein Name: Mannan-binding lectin serine protease 1
• Description of Target: Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5. Also plays a role in development (PubMed:21258343).
• Uniprot ID: P48740
• Protein Accession #: NP_001027019.1
• Nucleotide Accession #: NM_001031849.2
• Protein Size (# AA): His20~Ala447
• Molecular Weight: 53kDa