MARK Antibody - C-terminal region (OAAB17007)

Catalog No: OAAB17007

Size:400ul

MARK Antibody (S658) (Cat. # OAAB17007) western blot analysis in T47D cell line lysates (35ug/lane).This demonstrates the MARK antibody detected the MARK protein (arrow).

MARK Antibody (C-term) (Cat. # OAAB17007) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of MARK Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.

Product Info

• Predicted Species Reactivity: Human
• Product Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Clonality: Polyclonal
• Isotype: Ig
• Host: Rabbit
• Application: WB, IHC
• Additional Information: Precautions: MARK Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
  Function: Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3)
  Cellular Location: Cell membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton (By similarity). Note=Appears to localize to an intracellular network (By similarity)
  Tissue Location: Highly expressed in heart, skeletal muscle, brain, fetal brain and fetal kidney
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: This MARK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 643-674 amino acids from the C-terminal region of human MARK.
• Predicted Homology Based on Immunogen Sequence: Human
• Concentration: Approximately 0.5mg/ml. Actual concentration varies with each lot.
• Application Info: WB: 1:1000
  IHC-P: 1:10~50

Target Info

• Gene Symbol: MARK1
• Alias Symbols: MARK, Par1c, Par-1c
• NCBI Gene Id: 4139
• Protein Name: Serine/threonine-protein kinase MARK1
• Description of Target: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
• Uniprot ID: Q9P0L2
• Protein Accession #: NP_061120.3
• Molecular Weight: 89003 Da