Size:100 ul
$319.00
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ARP43232_P050
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Conjugation Options

ARP43232_P050-FITC Conjugated

ARP43232_P050-HRP Conjugated

ARP43232_P050-Biotin Conjugated

MARCH5 Antibody - N-terminal region (ARP43232_P050)

Catalog#: ARP43232_P050
Domestic: within 1-2 days delivery International: 1-2 days
More Information
Tested Species Reactivity Human
Predicted Species Reactivity Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Clonality Polyclonal
Host Rabbit
Application WB
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Replacement Item This antibody may replace item sc-109542 from Santa Cruz Biotechnology.
Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human MARCH5
Purification Affinity Purified
Predicted Homology Based on Immunogen Sequence Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
Complete computational species homology data Anti-MARCH5 (ARP43232_P050)
Peptide Sequence Synthetic peptide located within the following region: CRGSTKWVHQACLQRWVDEKQRGNSTARVACPQCNAEYLIVFPKLGPVVY
Concentration Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Blocking Peptide For anti-MARCH5 (ARP43232_P050) antibody is Catalog # AAP43232 (Previous Catalog # AAPP11307)
Datasheets/Manuals Printable datasheet for anti-MARCH5 (ARP43232_P050) antibody
Target Reference Karbowski,M., (2007) J. Cell Biol. 178 (1), 71-84
Publications

Cilenti, L. et al. Inactivation of Omi/HtrA2 protease leads to the deregulation of mitochondrial Mulan E3 ubiquitin ligase and increased mitophagy. Biochim. Biophys. Acta 1843, 1295-307 (2014). WB, Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish 24709290

Gene Symbol MARCH5
Official Gene Full Name Membrane-associated ring finger (C3HC4) 5
Alias Symbols FLJ20445, MARCH-V, MITOL, RNF153
NCBI Gene Id 54708
Protein Name E3 ubiquitin-protein ligase MARCH5
Description of Target MARCH5 is an ubiquitin ligase of the mitochondrial outer membrane that plays a role in the control of mitochondrial morphology by regulating mitofusin-2 (MFN2) and DRP1 (DNM1L). MARCH5 is a ubiquitin ligase of the mitochondrial outer membrane that plays a role in the control of mitochondrial morphology by regulating mitofusin-2 (MFN2; MIM 608507) and DRP1 (DNM1L; MIM 603850) (Nakamura et al., 2006 [PubMed 16936636]).[supplied by OMIM]. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-1502 AK000452.1 3-1504 1503-1863 BC015480.1 1463-1823 1864-1901 BE393612.1 438-475 1902-3713 BC015480.1 1852-3663 3714-3941 BC015480.1 3669-3896
Swissprot Id Q9NX47
Protein Accession # NP_060294
Nucleotide Accession # NM_017824
Protein Size (# AA) 278
Molecular Weight 31kDa
Tissue Tool Find tissues and cell lines supported by DNA array analysis to express MARCH5.
RNA Seq Find tissues and cell lines supported by RNA-seq analysis to express MARCH5.
Protein Interactions FATE1; UBE2W; UBC; DNM1L; MFN2; UBE2E1; FIS1; UBE2E3; MFN1; PARK2; MARCH5; CCNB1; UBE2D3; UBE2D2; UBE2D1; MAP1B; KIAA0368; SOD1; MAVS; TANK; TRAF6; AKTIP; UBE2T; UBE2N; UBE2I; UTRN;
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