MAPKAPK5 Antibody (Phospho-Thr182) (OASG06052)

Catalog No: OASG06052

Size:100 uL

Product Info

• Predicted Species Reactivity: Human, Mouse
• Product Format: Liquid. 1 mg/mL in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: WB, IHC
• Reconstitution and Storage: Store at -20C. Avoid repeated freeze/thaw cycles.
• Immunogen: Synthesized peptide derived from human PRAK around the phosphorylation site of T182. Location: 120-200aa.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Concentration: 1 mg/ml
• Target Post-Translational Modification: Phospho-Thr182
• Specificity: Phospho-PRAK (T182) Polyclonal Antibody detects endogenous levels of PRAK protein only when phosphorylated at T182.
• Application Info: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;

Target Info

• Gene Symbol: MAPKAPK5
• Gene Full Name: mitogen-activated protein kinase-activated protein kinase 5
• Alias Symbols: MK5, MK-5, PRAK, MAPKAP-K5
• NCBI Gene Id: 8550; 17165;
• Description of Target: The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported.
• Uniprot ID: Q8IW41, O54992
• Molecular Weight: 60 kDa