MAPK7 Recombinant Protein (OPCD05125)

Catalog No: OPCD05125

MAPK7 Recombinant Protein (OPCD05125) using SDS-PAGE

MAPK7 Recombinant Protein (OPCD05125) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Val560-Glu793
  Subcellular Location: Cytoplasm. Nucleus. Nucleus, PML body.
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His and GST Tag

Target Info

• Gene Symbol: MAPK7
• Gene Full Name: mitogen-activated protein kinase 7
• Alias Symbols: big MAP kinase 1;BMK1;BMK-1;BMK1 kinase;ERK4;ERK5;ERK-5;Extracellular signal-regulated kinase 5;extracellular-signal-regulated kinase 5;MAP kinase 7;MAPK 7;mitogen-activated protein kinase 7;PRKM7.
• NCBI Gene Id: 5598
• Protein Name: Mitogen-activated protein kinase 7
• Description of Target: Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction.
• Uniprot ID: Q13164
• Protein Accession #: NP_002740.2
• Nucleotide Accession #: NM_002749.3
• Protein Size (# AA): Val560~Glu793
• Molecular Weight: 53.36kDa