MAPK14 Antibody - C-terminal region (AVARP06004_T100)

Catalog No: AVARP06004_T100

WB Suggested Anti-MAPK14 Antibody
Titration: 0.625 ug/ml
Positive Control: Jurkat Whole CellMAPK14 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells

Host: Rabbit
Target Name: MAPK14
Sample Tissue: Human Jurkat Whole Cell
Antibody Dilution: 1ug/ml

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Horse, Pig, Rabbit, Sheep
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human MAPK14
• Purification: Protein A purified
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%
• Peptide Sequence: Synthetic peptide located within the following region: YHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
• Concentration: 1.0 mg/ml
• Blocking Peptide: For anti-MAPK14 (AVARP06004_T100) antibody is Catalog # AAP30459
• Sample Type Confirmation:

  MAPK14 is strongly supported by BioGPS gene expression data to be expressed in Jurkat

• Reference: Choi,S.Y., et al., (2006) J. Biol. Chem. 281 (11), 7049-7059

Target Info

• Gene Symbol: MAPK14
• Gene Full Name: Mitogen-activated protein kinase 14
• Alias Symbols: RK, p38, CSBP, EXIP, Mxi2, CSBP1, CSBP2, CSPB1, PRKM14, PRKM15, SAPK2A, p38ALPHA
• NCBI Gene Id: 1432
• Protein Name: Mitogen-activated protein kinase 14
• Description of Target: MAPK14 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
• Uniprot ID: Q16539
• Protein Accession #: NP_001306
• Nucleotide Accession #: NM_001315
• Protein Size (# AA): 360
• Molecular Weight: 41kDa
• Protein Interactions: MAPKAPK2; ATF2; PDX1; UBC; MARCKSL1; MAP2K3; MAPK14; ATF6; TCEAL1; USP11; PTPN11; OXCT1; NME1; WDR1; HSPD1; TYMS; ADSS; IQGAP1; MKNK1; MAPKAPK3; CNBP; AKT1; CCDC8; OBSL1; RRP1B; RPS6KA4; SRPK1; MAP2K6; MAPK11; NEB; MAZ; MKNK2; EEF2; DUSP9; ZFP36L1; ADRB2;