MAP3K9/MAP3K10 Antibody (Bi-Phospho-Thr312/266) (OAAF00460)

Catalog No: OAAF00460 (Formerly GWB-ASB903)

Size:100 ug

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Immunohistochemistry analysis of paraffin-embedded human brain, using MLK1/2 (Phospho-Thr312/266) Antibody. The picture on the right is treated with the synthesized peptide.

Product Info

• Predicted Species Reactivity: Human|Mouse
• Product Format: Liquid
• Clonality: Polyclonal
• Host: Rabbit
• Application: Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry|Immunohistochemistry-Paraffin
• Reconstitution and Storage: -20°C
• Immunogen: The antiserum was produced against synthesized peptide derived from human MLK1/2 around the phosphorylation site of Thr312/266.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Specificity: MAP3K9/MAP3K10 (Phospho-Thr312/266) antibody detects endogenous levels of MAP3K9/MAP3K10 only when phosphorylated at threonine 312/266.
• Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Dilution: The optimal working dilution should be determined by the end user.
• Application Info: IHC: 1:50~1:100; ELISA: 1:5000
• Reference: Durkin J.T., Biochemistry 43:16348-16355(2004).
  The MGC Project Team; Genome Res. 14:2121-2127(2004).
  Dorow D.S.,Nature 446:153-158(2007).

Target Info

• Gene Symbol: MAP3K10|MAP3K9
• Gene Full Name: mitogen-activated protein kinase kinase kinase 10|mitogen-activated protein kinase kinase kinase 9
• Alias Symbols: MEKK10;MEKK9;mitogen-activated protein kinase kinase kinase 10;mitogen-activated protein kinase kinase kinase 9;Mixed lineage kinase 1;mixed lineage kinase 1 (tyr and ser/thr specificity);mixed lineage kinase 2;MKN28 derived nonreceptor_type serine/threonine kinase;MKN28 kinase;MLK1;MLK2;MST;PRKE1;protein kinase MST.
• NCBI Gene Id: 4293|4294
• Protein Name: Mitogen-activated protein kinase kinase kinase 10|Mitogen-activated protein kinase kinase kinase 9
• Description of Target: Activates the JUN N-terminal pathway.|Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Plays also a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.
• Uniprot ID: P80192|Q02779
• Protein Accession #: NP_002437.2
• Molecular Weight: 121 kDa