MAP3K7IP1 Antibody - N-terminal region : FITC (ARP53182_P050-FITC)

Catalog No: ARP53182_P050-FITC

Size:100ul

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Product Info

• Predicted Species Reactivity: Human, Mouse, Rat, Dog, Guinea Pig, Pig, Rabbit
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer.
• Clonality: Polyclonal
• Host: Rabbit
• Conjugation: FITC: Fluorescein Isothiocyanate
• Application: WB
• Reconstitution and Storage: All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human MAP3K7IP1
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Dog: 100%; Guinea Pig: 93%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%
• Peptide Sequence: Synthetic peptide located within the following region: MAAQRRSLLQSEQQPSWTDDLPLCHLSGVGSASNRSYSADGKGTESHPPE
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-TAB1 (ARP53182_P050-FITC) antibody is Catalog # AAP53182 (Previous Catalog # AAPP36320)

Target Info

• Reference: Neil,J.R. (2008) Cancer Res. 68 (5), 1462-1470
• Gene Symbol: TAB1
• Gene Full Name: TGF-beta activated kinase 1/MAP3K7 binding protein 1
• Alias Symbols: 3'-Tab1, MAP3K7IP1
• NCBI Gene Id: 10454
• Protein Name: TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
• Description of Target: The specific function of the protein remains unknown.The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
• Uniprot ID: Q8IZW2
• Protein Accession #: NP_705717
• Nucleotide Accession #: NM_153497
• Protein Size (# AA): 462
• Molecular Weight: 50kDa
• Protein Interactions: MAGED1; BAG2; MAP3K7; TIRAP; MDM2; SLMAP; NPM1; BIRC3; TRIP6; PPP2R1A; PPP2CB; GRB2; FN1; CDK5RAP3; TAB2; CORO1A; WTAP; MAPK8IP1; UBC; MAPK14; BST2; MAPK12; HSP90AA1; NOTCH1; IKBKB; GRK5; EGFR; STE11; BIRC7; NAIP; XIAP; OGT; TAB3; NR2C2; ARRB2; ARAP1; ACA