MAP3K7 Antibody (Phospho-Thr187) (OASG07010)

Catalog No: OASG07010

Size:100 uL

Western Blot using 293T

Product Info

• Predicted Species Reactivity: Human, Mouse, Rat
• Product Format: Liquid. 1 mg/mL in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: WB, IHC
• Reconstitution and Storage: Store at -20C. Avoid repeated freeze/thaw cycles.
• Immunogen: Synthesized peptide derived from human Tak1 around the phosphorylation site of T187. Location: 130-210aa.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Concentration: 1 mg/ml
• Target Post-Translational Modification: Phospho-Thr187
• Specificity: Phospho-Tak1 (T187) Polyclonal Antibody detects endogenous levels of Tak1 protein only when phosphorylated at T187.
• Application Info: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000;

Target Info

• Gene Symbol: LOC100911000, MAP3K7
• Gene Full Name: mitogen-activated protein kinase kinase kinase 7
• Alias Symbols: CSCF, FMD2, TAK1, MEKK7, TGF1a
• NCBI Gene Id: 6885; 26409; 1.00911e+008
• Description of Target: The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
• Uniprot ID: O43318, Q62073, P0C8E4
• Molecular Weight: 60 kDa