MAP3K1 Antibody - C-terminal region (ARP48684_P050)

Catalog No: ARP48684_P050

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WB Suggested Anti-MAP3K1 Antibody Titration: 0.2-1 ug/ml
Positive Control: 721_B cell lysate

Host: Rabbit
Target Name: MAP3K1
Sample Tissue: Human Jurkat Whole Cell
Antibody Dilution: 1ug/ml

Host: Rabbit
Target Name: MAP3K1
Sample Tissue: Human Jurkat Whole Cell
Antibody Dilution: 1ug/ml

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human MAP3K1
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
• Peptide Sequence: Synthetic peptide located within the following region: LGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSH
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-MAP3K1 (ARP48684_P050) antibody is Catalog # AAP48684 (Previous Catalog # AAPY02585)
• Reference: Hancock,L., (er) Inflamm. Bowel Dis. (2008) In press

Target Info

• Gene Symbol: MAP3K1
• Gene Full Name: Mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
• Alias Symbols: MEKK, MEKK1, SRXY6, MEKK 1, MAPKKK1
• NCBI Gene Id: 4214
• Protein Name: Mitogen-activated protein kinase kinase kinase 1
• Description of Target: MAP3K, or MEK kinase, is a serine/threonine kinase that occupies a pivotal role in a network of phosphorylating enzymes integrating cellular responses to a number of mitogenic and metabolic stimuli, including insulin (MIM 176730) and many growth factors.MAP3K, or MEK kinase, is a serine/threonine kinase that occupies a pivotal role in a network of phosphorylating enzymes integrating cellular responses to a number of mitogenic and metabolic stimuli, including insulin (MIM 176730) and many growth factors.[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-983 AC008937.7 118022-119004 c 984-1536 AF042838.1 426-978 1537-1653 AC008937.7 68621-68737 c 1654-1802 AC008937.7 68100-68248 c 1803-2870 AF042838.1 1245-2312 2871-4167 AC008937.7 51211-52507 c 4168-4758 BU194120.1 127-717 4759-5154 DA889202.1 164-559 5155-7355 AC008937.7 38082-40282 c 7356-7522 AA602425.1 1-167 c
• Uniprot ID: Q13233
• Protein Accession #: NP_005912
• Nucleotide Accession #: NM_005921
• Protein Size (# AA): 1512
• Molecular Weight: 164kDa
• Protein Interactions: MAP2K4; CHUK; IKBKB; UBC; BRCA1; TRIM5; STK38; KAT5; SUMO1; RHOA; HIPK2; CRTC1; YWHAQ; DCAF7; DYRK1B; YWHAG; TRAF2; TP53; MAP4K2; MAP2K7; MAP2K1; MAPK9; MAPK8; MAPK1; PAK1; NFKBIA; MAP3K1; JUN; NR4A1; GSTP1; GSK3B; DYRK1A; UBE2I; FLNB; Axin1; ARHGAP4; ACT