MAGI2 Antibody - N-terminal region (ARP61404_P050)

Catalog No: ARP61404_P050

WB Suggested Anti-MAGI2 Antibody
Titration: 1.0 ug/ml
Positive Control: 293T Whole CellMAGI2 is strongly supported by BioGPS gene expression data to be expressed in Human HEK293T cells

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Dog, Guinea Pig, Horse, Rabbit, Zebrafish
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Dog: 100%; Guinea Pig: 86%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%; Zebrafish: 86%
• Peptide Sequence: Synthetic peptide located within the following region: EEEEEERPVVNGNGVVVTPESSEHEDKSAGASGEMPSQPYPAPVYSQPEE
• Concentration: 0.5 mg/ml
• Blocking Peptide: Catalog # AAP61404 (Previous Catalog # AAPP47522)
• Sample Type Confirmation:

  MAGI2 is strongly supported by BioGPS gene expression data to be expressed in HEK293T

• Publications:

  Corticosteroid treatment exacerbates nephrotic syndrome in a zebrafish model of magi2a knockout. Kidney Int. 95, 1079-1090 (2019). 31010479

  Doukhanine, E., Gavino, C., Haines, J. D., Almazan, G. & Richard, S. The QKI-6 RNA binding protein regulates actin-interacting protein-1 mRNA stability during oligodendrocyte differentiation. Mol. Biol. Cell 21, 3029-40 (2010). 20631256

Target Info

• Gene Symbol: MAGI2
• Gene Full Name: Membrane associated guanylate kinase, WW and PDZ domain containing 2
• Alias Symbols: AIP1, AIP-1, ARIP1, SSCAM, MAGI-2, NPHS15, ACVRIP1
• NCBI Gene Id: 9863
• Protein Name: Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2
• Description of Target: The protein encoded by this gene interacts with atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. This encoded protein is characterized by two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family.
• Uniprot ID: Q86UL8
• Protein Accession #: NP_036433
• Nucleotide Accession #: NM_012301
• Protein Size (# AA): 1455
• Molecular Weight: 160kDa
• Protein Interactions: BAI1; ARRDC3; CTNNB1; ADRB1; DSCAML1; PLXNB3; RAPGEF2; MAGI2; CTNND2; TGFA; GRID2; ATN1; DLL1; SMAD3; PTEN; ACVR2A;