MAF Antibody - middle region (P100617_P050)

Catalog No: P100617_P050

WB Suggested Anti-MAF Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: Hela cell lysate

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Zebrafish
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human MAF
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 78%; Rat: 100%; Zebrafish: 100%
• Peptide Sequence: Synthetic peptide located within the following region: LQQVDHLKQEISRLVRERDAYKEKYEKLVSSGFRENGSSSDNPSSPEFFI
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-MAF (P100617_P050) antibody is Catalog # AAP30933 (Previous Catalog # AAPP01657)
• Reference: Gosmain,Y., (2007) J. Biol. Chem. 282 (48), 35024-35034

Target Info

• Gene Symbol: MAF
• Gene Full Name: V-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)
• Alias Symbols: CCA4, AYGRP, c-MAF, CTRCT21
• NCBI Gene Id: 4094
• Protein Name: Transcription factor Maf
• Description of Target: MAF acts as a transcriptional activator or repressor. It is involved in embryonic lens fiber cell development. It recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation. MAF is also involved in the initial chondrocyte terminal differentiation and the disappearance of hypertrophic chondrocytes during endochondral bone development. When overexpressed, MAF represses anti-oxidant reponse element (ARE)-mediated transcription. It may be involved either as an oncogene or as a tumor suppressor, depending on the cell context.
• Uniprot ID: O75444-1
• Protein Accession #: NP_005351
• Nucleotide Accession #: NM_005360
• Protein Size (# AA): 403
• Molecular Weight: 42kDa
• Protein Interactions: MAFB; FOSL1; MAF; FOS; ATF4; AHR; SUMO1; UBE2I; PML; SIN3A; HDAC2; SMARCA5; CEBPA; KDM5B; MAFA; SOX9; EP300; MAFG; USF2; CREBBP; MYB; JUN; ETS1; HOXD12;