M-CSF Protein (OPSA11134)

Catalog No: OPSA11134 (Formerly GWB-B64851)

Size:10UG

Product Info

• Predicted Species Reactivity: Mouse
• Product Format: Lyophilized
• Application: Functional assay
• Additional Information: Activity: The ED₅₀ was determined by the dose-dependent stimulation of the proliferation of murine M-NFS-60 cells is < 1.0 ng/ml, corresponding to a specific activity of > 1 x 10⁶ units/mg.
  Approx Protein Conc: 0.1mg/ml
  Endotoxin Level: < 1EU/ug
  Label Protein Molar Ratio: Purified recombinant M-CSF expressed in E.coli
  Preservative: None present
• Reconstitution and Storage: -20°C
• Predicted Homology Based on Immunogen Sequence: Mouse
• Purification: Purified recombinant M-CSF expressed in E.coli
• Concentration: 0.1 mg/ml
• Purity: %98 by SDS PAGE and HPLC analysis
• Specificity: M-CSF (Macrophage colony-stimulating factor) is a potent lineage restricted haematopoietic growth factor and member of the CSF family of hormone-like glycoproteins, which plays a key role in the regulation of cellular differentiation, proliferation, and the survival of blood monocytes, tissue macrophages and their progenitor cells.
  Along with sRANKL/CD254/OPGL, M-CSF is essential for osteoclastogenesis, acting through the tyrosine kinase receptor c-fms (colony stimulating factor 1 receptor). A genetic defect in M-CSF is responsible for osteopetrosis in mice (op/op), which are severely deficient in mature macrophages and have a restricted capacity for bone remodelling.
  

Target Info

• Gene Symbol: Csf1
• Alias Symbols: op, Csf, CSF-, Csfm, M-CS, MCSF, C87615
• NCBI Gene Id: 12977
• Protein Name: Macrophage colony-stimulating factor 1
• Description of Target: RECOMBINANT MOUSE M-CSF
  
• Uniprot ID: P07141
• Protein Accession #: NP_001107001.1
• Protein Size (# AA): Recombinant
• Molecular Weight: 36.4kD (156 amino acid homodimer)