LSM1 Protein (OPPA02585)

Catalog No: OPPA02585 (Formerly GWB-BSP516)

Size:5UG

Product Info

• Predicted Species Reactivity: Human
• Product Format: The LSM1 solution (1 mg/ml) contains 20mM Tris-HCl buffer (pH 7.5), 1mM DTT, 10% glycerol and 0.1M NaCl. Physical appearance: Sterile Filtered colorless solution.
• Host: E. Coli
  Product Introduction: U6 snRNA-associated Sm-like protein LSm1 (LSM1) has a role in replication-dependent histone mRNA degradation and binds specifically to the 3''-terminal U-tract of U6 snRNA. Sm-like proteins include the Sm sequence motif, which consists of two regions separated by a linker of variable length that folds as a loop. The LSM1 protein facilitates RNA protein interactions and structural modifications which are required during ribosomal subunit assembly. The Sm-like proteins are believed to form a stable heteromer present in tri-snRNP particles, which are vital for pre-mRNA splicing. LSM1 is overexpressed in pancreatic cancer as well as in several breast cancer cell lines.
  Product Description: LSM1 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 153 amino acids (1-133 a.a.) and having a molecular mass of 17.3kDa. The LSM1 is purified by proprietary chromatographic techniques.
• Reconstitution and Storage: LSM1 should be stored desiccated below -18C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
• Purity: Greater than 95.0% as determined by SDS-PAGE.
• Peptide Sequence: MGSSHHHHHH SSGLVPRGSH MNYMPGTASL IEDIDKKHLV LLRDGRTLIG FLRSIDQFAN LVLHQTVERI HVGKKYGDIP RGIFVVRGEN VVLLGEIDLE KESDTPLQQV SIEEILEEQR VEQQTKLEAE KLKVQALKDR GLSIPRADTL DEY.

Target Info

• Gene Symbol: LSM1
• Alias Symbols: CASM, YJL124C
• NCBI Gene Id: 27257
• Protein Name: U6 snRNA-associated Sm-like protein LSm1
• Description of Target: Recombinant Human LSM1 Homolog, U6 Small Nuclear RNA Associated
• Uniprot ID: O15116
• Protein Accession #: NP_055277.1
• Protein Size (# AA): Recombinant