LRP8 Recombinant Protein (OPCD05032)

Catalog No: OPCD05032

LRP8 Recombinant Protein (OPCD05032) using SDS-PAGE

LRP8 Recombinant Protein (OPCD05032) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Pro696-Pro941
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 97%
• Source: E.coli
• Tag: N-terminal His and GST Tag

Target Info

• Gene Symbol: LRP8
• Gene Full Name: LDL receptor related protein 8
• Alias Symbols: ApoE receptor 2;APOER2;Apolipoprotein E receptor 2;HSZ75190;low density lipoprotein receptor-related protein 8, apolipoprotein e receptor;low-density lipoprotein receptor-related protein 8;LRP-8;MCI1.
• NCBI Gene Id: 7804
• Protein Name: Low-density lipoprotein receptor-related protein 8
• Description of Target: Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an endocytic receptor. Not required for endocytic uptake of SEPP1 in the kidney which is mediated by LRP2 (By similarity).
• Uniprot ID: Q14114
• Protein Accession #: NP_001018064.1
• Nucleotide Accession #: NM_001018054.2
• Protein Size (# AA): Pro696~Pro941
• Molecular Weight: 57kDa