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Catalog No: OPCD05027
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OPCD05027
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Datasheets/ManualsPrintable datasheet for LRP4 Recombinant Protein (OPCD05027)
Product Info
Predicted Species ReactivityHomo sapiens|Human
Product FormatFreeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
HostE.coli
ConjugationUnconjugated
ApplicationPositive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
Additional InformationEndotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
::Residues: Arg1610-Arg1885
::Subcellular Location: Membrane
Reconstitution and Storage2°C to 8°C|-80°C
Concentration200 ug/mL (prior to lyoph)
Purity> 90%
SourceE.coli
TagN-terminal His and GST Tag
Gene SymbolLRP4
Gene Full NameLDL receptor related protein 4
Alias SymbolsCLSS;CMS17;low-density lipoprotein receptor-related protein 4;LRP10;LRP-4;MEGF7;multiple epidermal growth factor-like domains 7;SOST2.
NCBI Gene Id4038
Protein NameLow-density lipoprotein receptor-related protein 4
Description of TargetMediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN-induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes. May play an essential role in the process of digit differentiation (By similarity).
Uniprot IDO75096
Protein Accession #NP_002325.2
Nucleotide Accession #NM_002334.3
Protein Size (# AA)Arg1610~Arg1885
Molecular Weight60kDa
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