LRP1 Antibody - middle region : Biotin (ARP58562_P050-Biotin)

Catalog No: ARP58562_P050-Biotin

Size:100ul

Product Info

• Publications:

  Behl, M., Zhang, Y., Monnot, A. D., Jiang, W. & Zheng, W. Increased beta-amyloid levels in the choroid plexus following lead exposure and the involvement of low-density lipoprotein receptor protein-1. Toxicol. Appl. Pharmacol. 240, 245-54 (2009). WB, Human 19501112

  Gu, H. et al. Lead exposure increases levels of β-amyloid in the brain and CSF and inhibits LRP1 expression in APP transgenic mice. Neurosci. Lett. 490, 16-20 (2011). WB, IHC, Human 21167913

  Hentschke, M. R. et al. Is the atherosclerotic phenotype of preeclamptic placentas due to altered lipoprotein concentrations and placental lipoprotein receptors? Role of a small-for-gestational-age phenotype. J. Lipid Res. 54, 2658-64 (2013). IHC, Human 23898049

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• Predicted Species Reactivity: Human
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer.
• Clonality: Polyclonal
• Host: Rabbit
• Conjugation: Biotin
• Application: IHC, WB
• Reconstitution and Storage: All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human LRP1
• Purification: Affinity Purified
• Peptide Sequence: Synthetic peptide located within the following region: ATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCAR
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-LRP1 (ARP58562_P050-Biotin) antibody is Catalog # AAP58562 (Previous Catalog # AAPP35508)

Target Info

• Gene Symbol: LRP1
• Gene Full Name: Low density lipoprotein receptor-related protein 1
• Alias Symbols: APR, KPA, LRP, A2MR, CD91, APOER, LRP1A, TGFBR5, IGFBP3R, IGFBP-3R, IGFBP3R1
• NCBI Gene Id: 4035
• Protein Name: Prolow-density lipoprotein receptor-related protein 1
• Description of Target: Low-density lipoprotein receptor-related protein 1 (.-2-macroglobulin receptor, LRP1) is a multifunctional endocytic receptor with an important role in regulating the activity of proteinases in the extracellular matrix. It is also involved in intracellular signaling and the subcellular translocation of preassembled signaling complexes from the plasma membrane.
• Uniprot ID: Q07954
• Protein Accession #: AAH21204
• Nucleotide Accession #: NM_002332
• Protein Size (# AA): 439
• Molecular Weight: 48kDa
• Protein Interactions: UBC; COPS5; APP; RANBP9; SKIL; CHFR; CUBN; FBXO6; ANKS1B; RIC8B; PID1; CC2D1A; MAPRE1; HNRNPDL; MAPK8IP1; SNRNP70; APOE; CACNA1A; USP3; CAV1; MMP14; SHC1; MMP13; SERPINA1; F9; F8; LPL; HSP90B1; SRC; PDGFB; THBS1; SCN3A; PLAUR; PLAT; SERPINE1; MDK; LIPC; L