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LOXL1 antibody - N-terminal region (ARP54780_P050)

100 ul
$319.00
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Conjugation Options

ARP54780_P050-FITC Conjugated

ARP54780_P050-HRP Conjugated

ARP54780_P050-Biotin Conjugated

Gene Symbol:
LOXL1
NCBI Gene Id:
4016
Official Gene Full Name:
Lysyl oxidase-like 1
Protein Name:
Lysyl oxidase homolog 1
Swissprot Id:
Q08397
Protein Accession #:
NP_005567
Nucleotide Accession #:
NM_005576
Alias Symbols:
LOL, LOXL
Replacement Item:
This antibody may replace item sc-166632 from Santa Cruz Biotechnology.
Description of Target:
LOXL1 is a member of the lysyl oxidase family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Protein Size (# AA):
574
Molecular Weight:
63 kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Affinity Purified
Application:
WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express LOXL1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express LOXL1.
Immunogen:
The immunogen is a synthetic peptide directed towards the N terminal region of human LOXL1
Tested Species Reactivity:
Human
Predicted Homology Based on Immunogen Sequence:
Cow: 83%; Guinea Pig: 100%; Horse: 92%; Human: 100%; Mouse: 100%; Rabbit: 86%; Rat: 100%
Complete computational species homology data:
Anti-LOXL1 (ARP54780_P050)
Peptide Sequence:
Synthetic peptide located within the following region: RWRQLIQWENNGQVYSLLNSGSEYVPAGPQRSESSSRVLLAGAPQAQQRR
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
ATXN1; CUL2; FBLN5; ELN;
Blocking Peptide:
For anti-LOXL1 (ARP54780_P050) antibody is Catalog # AAP54780 (Previous Catalog # AAPP31575)
Datasheets/Manuals:
Printable datasheet for anti-LOXL1 (ARP54780_P050) antibody
Target Reference:
Ozaki,M., (er) Invest. Ophthalmol. Vis. Sci. (2008) In press
Publications:

Ohmura, H. et al. Cardiomyocyte-specific transgenic expression of lysyl oxidase-like protein-1 induces cardiac hypertrophy in mice. Hypertens. Res. 35, 1063-8 (2012). WB, Cow, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat 22763477

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