Catalog No: OOMC00041
Price: $0.00
SKU
OOMC00041
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Datasheets/Manuals | Printable datasheet for OOMC00041 |
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Product Format | Powder |
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Additional Information | CAS: 124750-99-8 Molecular Formula: C22H22ClKN6O |
:: | Chemical Name: 2-Butyl-4-chloro-1-{[2’-(1H-tetrazol-5-yl)(1,1’-biphenyl)-4-yl]methyl}-1H-imidazole-5-methanol, potassium salt |
:: | Primary Activity: Angiotensin AT1 receptor antagonist |
:: | COVID-19 Rationale: In clinical trials to treat COVID-19 |
Reconstitution and Storage | Soluble in DMSO (up to 20 mg/ml). Store at -20C. |
Purity | > 98% |
Reference | 1) Merck 14:5583 2) Chiu et al. (1990), Nonpeptide angiotensin II receptor antagonists. VII. Cellular and biochemical pharmacology of DuP 753, an orally active antihypertensive agent; J. Pharmacol. Exp. Ther., 252 711 3) McIntyre et al. (1997), Losartan, an orally active angiotensin (AT1) receptor antagonist: a review of it’s efficacy and safety in essential hypertension; Pharmacol. Ther., 74 181 4) Diop-Frimpong et al. (2011), Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors; Proc. Natl. Acad. Sci. USA, 108 2909 5) Pantazi et al. (2015), Losartan activates sirtuin 1 in rat reduced-size orthotopic liver transplantation; World J. Gastroenterol., 21 8021 6) Kumar et al. (2015), Neuroprotective mechanism of losartan and its interaction with nimesulide against chronic fatigue stress; Inflammopharmacology, 23 291 7) Miguel-Carrasco et al. (2017), Mechanisms underlying the cardiac antifibrotic effects of losartan metabolites; Sci. Rep. 7 41865 |
Alias Symbols | DUP-753 |
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Molecular Weight | 461.01 g/mol |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
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