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Catalog No: OOMC00041
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OOMC00041
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Losartan potassium (OOMC00041)

Datasheets/ManualsPrintable datasheet for OOMC00041
Product Info
Product FormatPowder
Additional InformationCAS: 124750-99-8
Molecular Formula: C22H22ClKN6O
::Chemical Name: 2-Butyl-4-chloro-1-{[2’-(1H-tetrazol-5-yl)(1,1’-biphenyl)-4-yl]methyl}-1H-imidazole-5-methanol, potassium salt
::Primary Activity: Angiotensin AT1 receptor antagonist
::COVID-19 Rationale: In clinical trials to treat COVID-19
Reconstitution and StorageSoluble in DMSO (up to 20 mg/ml). Store at -20C.
Purity> 98%
Reference1) Merck 14:5583 2) Chiu et al. (1990), Nonpeptide angiotensin II receptor antagonists. VII. Cellular and biochemical pharmacology of DuP 753, an orally active antihypertensive agent; J. Pharmacol. Exp. Ther., 252 711 3) McIntyre et al. (1997), Losartan, an orally active angiotensin (AT1) receptor antagonist: a review of it’s efficacy and safety in essential hypertension; Pharmacol. Ther., 74 181 4) Diop-Frimpong et al. (2011), Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors; Proc. Natl. Acad. Sci. USA, 108 2909 5) Pantazi et al. (2015), Losartan activates sirtuin 1 in rat reduced-size orthotopic liver transplantation; World J. Gastroenterol., 21 8021 6) Kumar et al. (2015), Neuroprotective mechanism of losartan and its interaction with nimesulide against chronic fatigue stress; Inflammopharmacology, 23 291 7) Miguel-Carrasco et al. (2017), Mechanisms underlying the cardiac antifibrotic effects of losartan metabolites; Sci. Rep. 7 41865
Alias SymbolsDUP-753
Molecular Weight461.01 g/mol
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