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Catalog No: OACA10083
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OACA10083
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  • $55: Antibody & Protein in US
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Datasheets/ManualsPrintable datasheet for LIN28B Antibody (OACA10083) (OACA10083)
Product Info
Predicted Species ReactivityHuman
Product FormatLiquid
ClonalityPolyclonal
IsotypeIgG
HostRabbit
ConjugationUnconjugated
ApplicationEnzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry
Reconstitution and Storage-20°C or -80°C
ImmunogenRecombinant Human Protein lin-28 homolog B protein (166-250AA)
PurificationProtein G Purified
Preservative0.03% Proclin 300
Formulation50% Glycerol, 0.01M PBS, PH 7.4
Purity>95%
Gene SymbolLIN28B
Gene Full Namelin-28 homolog B
Alias SymbolsCSDD2;Lin-28.2;lin-28B;protein lin-28 homolog B.
NCBI Gene Id389421
Protein NameProtein lin-28 homolog B
Description of TargetSuppressor of microRNA (miRNA) biogenesis, including that of let-7 and possibly of miR107, miR-143 and miR-200c. Binds primary let-7 transcripts (pri-let-7), including pri-let-7g and pri-let-7a-1, and sequester them in the nucleolus, away from the microprocessor complex, hence preventing their processing into mature miRNA (PubMed:22118463). Does not act on pri-miR21 (PubMed:22118463). The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state of embryonic stem cells by preventing let-7-mediated differentiation. When overexpressed, recruits ZCCHC11/TUT4 uridylyltransferase to pre-let-7 transcripts, leading to their terminal uridylation and degradation (PubMed:19703396). This activity might not be relevant in vivo, as LIN28B-mediated inhibition of let-7 miRNA maturation appears to be ZCCHC11-independent (PubMed:22118463). Interaction with target pre-miRNAs occurs via an 5'-GGAG-3' motif in the pre-miRNA terminal loop. Mediates MYC-induced let-7 repression (By similarity). When overexpressed, isoform 1 stimulates growth of the breast adenocarcinoma cell line MCF-7. Isoform 2 has no effect on cell growth.
Uniprot IDQ6ZN17
Protein Accession #NP_001004317
Nucleotide Accession #NM_001004317
  1. What is the species homology for "LIN28B Antibody (OACA10083)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".

  2. How long will it take to receive "LIN28B Antibody (OACA10083)"?

    This item is available "Domestic: Antibody & Kits: 2 weeks | Proteins: 4-6 weeks | International: Antibody & Kits: 2 weeks | Proteins: 4-6 weeks".

  3. What buffer format is "LIN28B Antibody (OACA10083)" provided in?

    This item is provided in "Liquid".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "LIN28B Antibody (OACA10083)"?

    This target may also be called "CSDD2;Lin-28.2;lin-28B;protein lin-28 homolog B." in publications.

  5. What is the shipping cost for "LIN28B Antibody (OACA10083)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "LIN28B Antibody (OACA10083)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "LIN28B Antibody (OACA10083)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "LIN28B Antibody (OACA10083)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "LIN28B"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "LIN28B"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "LIN28B"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "LIN28B"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "LIN28B"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "LIN28B"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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