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Catalog No: OAAB21410
Size:100ul
Price: $450.00
SKU
OAAB21410
Availability: Domestic: within 1-2 week delivery | International: within 1-2 week delivery
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Datasheets/ManualsPrintable datasheet for anti-LIN28A (OAAB21410) antibody
Product Info
Predicted Species ReactivityHuman, Mouse
Product FormatLiquid
ClonalityMonoclonal
HostRabbit
ApplicationWB
Additional InformationFunction: Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression (By similarity). Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let- 7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre- let-7 in embryonic stem (ES) cells contributes to the maintenance of ES cells. In contrast, LIN28A down-regulation in neural stem cells by miR-125, allows the processing of pre-let-7. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation.
Reconstitution and StorageMaintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Predicted Homology Based on Immunogen SequenceHuman, Mouse
Preservative0.02% Sodium Azide and 50% glycerol
FormulationPurified mouse monoclonal in PBS (pH 7.4)containing with 0.2% sodium azide and 50% glycerol.
Application InfoWB: 1:1000
ReferenceMoss E.G.,et al.Dev. Biol. 258:432-442(2003).
Moss E.G.,et al.Dev. Biol. 262:361-361(2003).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Sempere L.F.,et al.Genome Biol. 5:R13.1-R13.11(2004).
Gene SymbolLIN28A
Gene Full Namelin-28 homolog A
Alias SymbolsCSDD1, LIN28, LIN-28, ZCCHC1, lin-28A
NCBI Gene Id79727
Description of TargetThis gene encodes a LIN-28 family RNA-binding protein that acts as a posttranscriptional regulator of genes involved in developmental timing and self-renewal in embryonic stem cells. The encoded protein functions through direct interaction with target mRNAs and by disrupting the maturation of certain miRNAs involved in embryonic development. This protein prevents the terminal processing of the LET7 family of microRNAs which are major regulators of cellular growth and differentiation. Aberrant expression of this gene is associated with cancer progression in multiple tissues.
Uniprot IDQ9H9Z2
Protein Accession #NP_078950.1
Nucleotide Accession #NM_024674.5
Molecular Weight23 kDa
  1. What is the species homology for "LIN28A Antibody (OAAB21410)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human, Mouse".

  2. How long will it take to receive "LIN28A Antibody (OAAB21410)"?

    This item is available "Domestic: within 1-2 week delivery | International: within 1-2 week delivery".

  3. What buffer format is "LIN28A Antibody (OAAB21410)" provided in?

    This item is provided in "Liquid".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "LIN28A Antibody (OAAB21410)"?

    This target may also be called "CSDD1, LIN28, LIN-28, ZCCHC1, lin-28A" in publications.

  5. What is the shipping cost for "LIN28A Antibody (OAAB21410)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "LIN28A Antibody (OAAB21410)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "LIN28A Antibody (OAAB21410)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "23 kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "LIN28A Antibody (OAAB21410)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "LIN28A"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "LIN28A"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "LIN28A"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "LIN28A"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "LIN28A"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "LIN28A"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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