LGALS3 Protein (OPPA02216)

Catalog No: OPPA02216 (Formerly GWB-A27E9A)

Size:5UG

Product Info

• Predicted Species Reactivity: Human
• Product Format: The Galectin-3 His tag protein solution contains 20mM Tris-HCl pH-8, 10% glycerol & 1mM DTT. Physical appearance: Sterile Filtered colorless solution.
• Host: E. Coli
  Product Introduction: Galectin-3 mediates with the alpha-3, beta-1 integrin the stimulation by cspg4 of endothelial cells migration. Galectin-3 plays an necessary part during the acquisition of vasculogenic mimicry and angiogenic properties associated with melanoma progression. LGALS3 overexpression is highly expressed in early stages of papillary carcinoma, and its expression intensity declines during tumor progression. Serum levels of LGALS3 are high in patients with thyroid malignancy but there is considerable overlap in serum LGALS3 concentrations between those with benign and malignant nodular thyroid disease. LGLAS3 takes part as an immune regulator to inhibit T-cell immune responses and promote tumor growth, as a result providing a new mechanism for tumor immune tolerance.
  Product Description: LGALS3 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 270 amino acids (1-250 a.a.) and having a molecular mass of 28.3 kDa. The LGALS3 is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
• Reconstitution and Storage: LGALS3 although stable 4C for 4 weeks, should be stored desiccated below -18C. For long term storage it is recommended to add a carrier protein (0. 1% HSA or BSA). Please prevent freeze-thaw cycles.
• Purity: Greater than 95.0% as determined by SDS-PAGE.
• Peptide Sequence: MGSSHHHHHH SSGLVPRGSH MADNFSLHDA LSGSGNPNPQ GWPGAWGNQP AGAGGYPGAS YPGAYPGQAP PGAYPGQAPP GAYPGAPGAY PGAPAPGVYP GPPSGPGAYP SSGQPSATGA YPATGPYGAP AGPLIVPYNL PLPGGVVPRM LITILGTVKP NANRIALDFQ RGNDVAFHFN PRFNENNRRV IVCNTKLDNN WGREERQSVF PFESGKPFKI QVLVEPDHFK VAVNDAHLLQ YNHRVKKLNE ISKLGISGDI DLTSASYTMI.

Target Info

• Gene Symbol: LGALS3 His
• Alias Symbols: L31, GAL3, MAC2, CBP35, GALBP, GALIG, LGALS2
• NCBI Gene Id: 3958
• Protein Name: Galectin-3
• Description of Target: Recombinant Human Galectin-3 His Tag
• Uniprot ID: P17931
• Protein Accession #: NP_002297.2
• Protein Size (# AA): Recombinant