LEPTIN Recombinant Protein (OPSA11045)

Catalog No: OPSA11045 (Formerly GWB-F9CD71)

Size:1MG

Product Info

• Predicted Species Reactivity: Human
• Product Format: Lyophilized. Lyophilized with 0.1% TFA
• Application: Enzyme-linked immunosorbent assay|Functional assay|Western blot
• Additional Information: Activity: This product is biologically active in the ob/ob mouse obesity model. The ob/ob mice were treated via intraperitoneal injection once daily at a dose of 5 ug Leptin/gm of body weight for 7 days. Significant effects on body weight, food consumption, and plasma glucose levels were observed to saline-treated controls.
  Approx Protein Conc: 1.0mg/ml
  Endotoxin Level: < 1EU/ug
  Label Protein Molar Ratio: Purified recombinant leptin expressed in E.coli.
  Preservative: None present
• Reconstitution and Storage: -20°C
• Predicted Homology Based on Immunogen Sequence: Human
• Purification: Purified recombinant leptin expressed in E.coli. Sterile filtered through a 0.2 micron filter
• Concentration: 1 mg/ml
• Purity: >98% by SDS PAGE and HPLC analysis.
• Specificity: Leptin is a major adipose-derived hormone and member of the leptin family, which plays a key role in appetite control and the regulation of energy expenditure.
  Secreted leptin associates with proteins within the bloodstream and is transported to the brain, where it inhibits or up-regulates the activity of neuropeptides such as neuropeptide Y (NPY) and alpha-melanocyte-stimulating hormone respectively. Leptin is a recognised marker of obesity, with a correlation between circulating levels of leptin and body fat mass, and defects in leptin production result in severe obesity. Regulators of leptin expression include insulin, cortisol, cAMP and thiazolidinediones.
  

Target Info

• Gene Symbol: LEP
• Alias Symbols: OB, OBS, LEPD
• NCBI Gene Id: 3952
• Protein Name: Leptin
• Description of Target: RECOMBINANT HUMAN LEPTIN
  
• Uniprot ID: P41159
• Protein Accession #: NP_000221.1
• Protein Size (# AA): Recombinant
• Molecular Weight: 16.0kD (147 amino acid residues).