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LEPTIN Recombinant Protein (OPSA11045)

1 mg
$459.00
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Gene Symbol:
LEP
Alias Symbols:
OB, OBS, FLJ94114, LEP
NCBI Gene Id:
3952
Swissprot Id:
P41159
Protein Accession #:
NP_000221.1
Protein Name:
Leptin
Description of Target:
RECOMBINANT HUMAN LEPTIN
Protein Size (# AA):
167
Molecular Weight:
16.0kD (147 amino acid residues).
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express LEP.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express LEP.
Product Format:
Purified recombinant protein - lyophilised
Predicted Homology Based on Immunogen Sequence:
Human
Predicted Species Reactivity:
Human
Purity:
>98% by SDS PAGE and HPLC analysis.
Specificity:
Leptin is a major adipose-derived hormone and member of the leptin family, which plays a key role in appetite control and the regulation of energy expenditure.
Secreted leptin associates with proteins within the bloodstream and is transported to the brain, where it inhibits or up-regulates the activity of neuropeptides such as neuropeptide Y (NPY) and alpha-melanocyte-stimulating hormone respectively. Leptin is a recognised marker of obesity, with a correlation between circulating levels of leptin and body fat mass, and defects in leptin production result in severe obesity. Regulators of leptin expression include insulin, cortisol, cAMP and thiazolidinediones.
Additional Information:
Activity: This product is biologically active in the ob/ob mouse obesity model. The ob/ob mice were treated via intraperitoneal injection once daily at a dose of 5 ug Leptin/gm of body weight for 7 days. Significant effects on body weight, food consumption, and plasma glucose levels were observed to saline-treated controls.
Approx Protein Conc: 1.0mg/ml
:::
Endotoxin Level: < 1EU/ug
:::
Label Protein Molar Ratio: Purified recombinant leptin expressed in E.coli.
Preservative: None present
Reconstitution and Storage:
Reconstitution: Reconstitute with 1.0ml distilled water.
Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. Aviva Systems Biology recommend that the vial is gently mixed after reconstitution.
Datasheets/Manuals:
Printable datasheet for OPSA11045

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