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LEPTIN Recombinant Protein (OPSA11045)

1 mg
$459.00
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Predicted Species Reactivity:
Human
Product Format:
Purified recombinant protein - lyophilised
Additional Information:
Activity: This product is biologically active in the ob/ob mouse obesity model. The ob/ob mice were treated via intraperitoneal injection once daily at a dose of 5 ug Leptin/gm of body weight for 7 days. Significant effects on body weight, food consumption, and plasma glucose levels were observed to saline-treated controls.
Approx Protein Conc: 1.0mg/ml
:::
Endotoxin Level: < 1EU/ug
:::
Label Protein Molar Ratio: Purified recombinant leptin expressed in E.coli.
Preservative: None present
Reconstitution and Storage:
Reconstitution: Reconstitute with 1.0ml distilled water.
Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. Aviva Systems Biology recommend that the vial is gently mixed after reconstitution.
Gene Symbol:
LEP
Alias Symbols:
OB, OBS, FLJ94114, LEP
NCBI Gene Id:
3952
Protein Name:
Leptin
Description of Target:
RECOMBINANT HUMAN LEPTIN
Swissprot Id:
P41159
Protein Accession #:
NP_000221.1
Protein Size (# AA):
167
Molecular Weight:
16.0kD (147 amino acid residues).
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express LEP.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express LEP.
Predicted Homology Based on Immunogen Sequence:
Human
Purity:
>98% by SDS PAGE and HPLC analysis.
Specificity:
Leptin is a major adipose-derived hormone and member of the leptin family, which plays a key role in appetite control and the regulation of energy expenditure.
Secreted leptin associates with proteins within the bloodstream and is transported to the brain, where it inhibits or up-regulates the activity of neuropeptides such as neuropeptide Y (NPY) and alpha-melanocyte-stimulating hormone respectively. Leptin is a recognised marker of obesity, with a correlation between circulating levels of leptin and body fat mass, and defects in leptin production result in severe obesity. Regulators of leptin expression include insulin, cortisol, cAMP and thiazolidinediones.
Datasheets/Manuals:
Printable datasheet for OPSA11045

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