Catalog No: OOMC00042
Price: $0.00
SKU
OOMC00042
Availability: Domestic: within 1-2 weeks delivery | International: 1-2 weeks
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| Datasheets/Manuals | Printable datasheet for OOMC00042 |
|---|
| Product Format | Powder |
|---|---|
| Additional Information | CAS: 75706-12-6 Molecular Formula: C12H9F3N2O2 |
| :: | Chemical Name: 5-Methyl-N-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxamide |
| :: | Primary Activity: Immunosuppressant, DHODH inhibitor |
| :: | COVID-19 Rationale: Inhibits Sars-CoV-2 in cells, possibly through UTP depletion |
| Reconstitution and Storage | Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 25 mg/ml). Store at room temperature. |
| Purity | > 98% |
| Reference | 1) Teschner et al. (2010), Leflunomide: a drug with a potential beyond rheumatology; Immunotherapy, 2 637 2) Davis et al. (1996), The immunosuppressive metabolite of leflunomide is a potent inhibitor of human dihydroorotate dehydrogenase; Biochemistry, 35 1270 3) Latchoumycandane et al. (2007), Mitochondrial protection by the JNK ninhibitor leflunomide rescues mice from acetaminophen-induced liver injury; Hepatology, 45 412 |
| Alias Symbols | RS-34821 |
|---|---|
| Molecular Weight | 270.21 g/mol |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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