Size:100 ul
$329.00
In Stock
SKU
OAAB21880
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More Information
Predicted Species Reactivity Human, Mouse
Product Format Liquid
Clonality Polyclonal
Host Rabbit
Application WB, IF, IHC-P
Additional Information Function: Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP3. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling. Isoform 5 transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. Isoform 1 transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells.
Reconstitution and Storage Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Replacement Item This antibody may replace item sc-28687 from Santa Cruz Biotechnology.
Predicted Homology Based on Immunogen Sequence Human, Mouse
Datasheets/Manuals Printable datasheet for anti-LEF1 (OAAB21880) antibody
Preservative 0.03% Proclin300 and 50% glycerol
Formulation 0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
Application Info WB: 1:100~1:500
IHC-P: 1:100~1:500
Gene Symbol LEF1
Official Gene Full Name lymphoid enhancer binding factor 1
Alias Symbols LEF-1, TCF10, TCF7L3, TCF1ALPHA
NCBI Gene Id 51176
Description of Target This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants.
Swissprot Id Q9UJU2
Protein Accession # NP_001124185.1
Nucleotide Accession # NM_001130713.2
Molecular Weight 44 kDa
Tissue Tool Find tissues and cell lines supported by DNA array analysis to express LEF1.
RNA Seq Find tissues and cell lines supported by RNA-seq analysis to express LEF1.
  1. What is the species homology for "LEF1 Antibody (OAAB21880)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human, Mouse".

  2. How long will it take to receive "LEF1 Antibody (OAAB21880)"?

    This item is available "Domestic: within 1 week delivery | International: 1 week".

  3. What buffer format is "LEF1 Antibody (OAAB21880)" provided in?

    This item is provided in "Liquid".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "LEF1 Antibody (OAAB21880)"?

    This target may also be called "LEF-1, TCF10, TCF7L3, TCF1ALPHA" in publications.

  5. What is the shipping cost for "LEF1 Antibody (OAAB21880)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "LEF1 Antibody (OAAB21880)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "LEF1 Antibody (OAAB21880)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "44 kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "LEF1 Antibody (OAAB21880)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data tab on the product page.

  10. What are positive controls for "LEF1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "LEF1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "LEF1"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "LEF1"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "LEF1"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "LEF1"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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