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LEF1 Antibody (OAAB21880)

100 ul
$329.00
In Stock
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Predicted Species Reactivity:
Human, Mouse
Product Format:
Liquid
Clonality:
Polyclonal
Host:
Rabbit
Application:
WB, IF, IHC-P
Additional Information:
Function: Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP3. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling. Isoform 5 transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. Isoform 1 transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells.
Reconstitution and Storage:
Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Gene Symbol:
LEF1
Official Gene Full Name:
lymphoid enhancer binding factor 1
NCBI Gene Id:
51176
Swissprot Id:
Q9UJU2
Protein Accession #:
NP_001124185.1
Nucleotide Accession #:
NM_001130713.2
Alias Symbols:
LEF-1, TCF10, TCF7L3, TCF1ALPHA
Replacement Item:
This antibody may replace item sc-28687 from Santa Cruz Biotechnology.
Description of Target:
This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants.
Molecular Weight:
44 kDa
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express LEF1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express LEF1.
Predicted Homology Based on Immunogen Sequence:
Human, Mouse
Datasheets/Manuals:
Printable datasheet for anti-LEF1 (OAAB21880) antibody
Preservative:
0.03% Proclin300 and 50% glycerol
Formulation:
0.01M TBS (pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
Application Info:
WB: 1:100~1:500
IHC-P: 1:100~1:500

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