LCN2 Antibody (OABF00666)

Catalog No: OABF00666

Size:100UL

Formalin-fixed and paraffin embedded human colon carcinoma labeled with Rabbit Anti NGAL/Lipocalin 2 Polyclonal Antibody, Unconjugated (OABF00666) at 1:200 followed by conjugation to the secondary antibody and DAB staining

Product Info

• Predicted Species Reactivity: Bovine|Dog|Human|Mouse|Porcine|Rabbit|Rat
• Product Format: Liquid. Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Flow cytometry|Immunocytochemistry|Immunofluorescence|Immunohistochemistry-Frozen|Immunohistochemistry-Paraffin
• Additional Information: Subcellular location: Secreted
• Reconstitution and Storage: -20°C
• Immunogen: KLH conjugated synthetic peptide derived from human Lipocalin 2
• Purification: Protein A Purified
• Concentration: 1 ug/ul
• Application Info: IHC-P: : 1:100 - 500

Target Info

• Gene Symbol: LCN2
• Gene Full Name: lipocalin 2
• Alias Symbols: 24p3;25 kDa alpha-2-microglobulin-related subunit of MMP-9;Lipocalin-2;migration-stimulating factor inhibitor;MSFI;neutrophil gelatinase-associated lipocalin;NGAL;oncogene 24p3;p25;siderocalin LCN2.
• NCBI Gene Id: 3934
• Protein Name: Neutrophil gelatinase-associated lipocalin
• Description of Target: Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.
• Uniprot ID: P80188