LATS1 Antibody (Phospho-Thr1079/1041) (OASG04208)

Catalog No: OASG04208

Size:100 uL

Product Info

• Predicted Species Reactivity: Human, Mouse
• Product Format: Liquid. 1 mg/mL in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: ELISA, IF, IHC
• Reconstitution and Storage: Store at -20C. Avoid repeated freeze/thaw cycles.
• Immunogen: Synthesized peptide derived from human LATS1/2 around the phosphorylation site of T1079/1041. Location: 1010-1090aa.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Concentration: 1 mg/ml
• Target Post-Translational Modification: Phospho-Thr1079/1041
• Specificity: Phospho-LATS1/2 (T1079/1041) Polyclonal Antibody detects endogenous levels of LATS1/2 protein only when phosphorylated at T1079/1041.
• Application Info: IHC 1:100-1:300; ELISA 1:20000;

Target Info

• Gene Symbol: LATS1, LATS2
• Gene Full Name: large tumor suppressor kinase 1
• Alias Symbols: wts, WARTS
• NCBI Gene Id: 9113; 26524; 16798; 50523;
• Description of Target: The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. Two protein-coding transcripts and one non-protein coding transcript have been found for this gene.
• Uniprot ID: O95835, Q9NRM7, Q8BYR2, Q7TSJ6
• Molecular Weight: 130 kDa