LATS1 Antibody (OACA09411)

Catalog No: OACA09411

Immunohistochemistry of paraffin-embedded human liver cancer at dilution of 1:100

Immunohistochemistry of paraffin-embedded human placenta tissue at dilution of 1:100

Immunofluorescent analysis of HeLa cells at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: IHC, IF
• Reconstitution and Storage: Shipped at 4C. Upon delivery aliquot and store at -20C or -80C. Avoid repeated freeze.
• Immunogen: Recombinant human Serine/threonine-protein kinase LATS1 protein (1-280AA)
• Purification: Protein G purified
• Preservative: 0.03% Proclin 300
• Formulation: 50% Glycerol, 0.01M PBS, PH 7.4
• Purity: >95%

Target Info

• Gene Symbol: LATS1
• Gene Full Name: large tumor suppressor kinase 1
• Alias Symbols: wts, WARTS
• NCBI Gene Id: 9113
• Protein Name: Serine/threonine-protein kinase LATS1
• Description of Target: Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function.
• Uniprot ID: O95835
• Protein Accession #: NP_001257448
• Nucleotide Accession #: NM_001270519