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Catalog No: OACA09411
Price: $0.00
SKU
OACA09411
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  • $55: Antibody & Protein in US
  • $55 + $25/Kit in US
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Datasheets/ManualsPrintable datasheet for LATS1 Antibody (OACA09411) (OACA09411)
Product Info
Predicted Species ReactivityHuman
Product FormatLiquid
ClonalityPolyclonal
IsotypeIgG
HostRabbit
ConjugationUnconjugated
ApplicationEnzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry|Immunoprecipitation
Reconstitution and Storage-20°C or -80°C
ImmunogenRecombinant Human Serine/threonine-protein kinase LATS1 protein (1-280AA)
PurificationProtein G Purified
Preservative0.03% Proclin 300
Formulation50% Glycerol, 0.01M PBS, PH 7.4
Purity>95%
Gene SymbolLATS1
Gene Full Namelarge tumor suppressor kinase 1
Alias Symbolsh-warts;large tumor suppressor homolog 1;LATS (large tumor suppressor, Drosophila) homolog 1;LATS, large tumor suppressor, homolog 1;serine/threonine-protein kinase LATS1;WARTS;WARTS protein kinase;wts.
NCBI Gene Id9113
Protein NameSerine/threonine-protein kinase LATS1
Description of TargetNegative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function. Plays a role in mammary gland epithelial cells differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1 (PubMed:28068668).
Uniprot IDO95835
Protein Accession #NP_001257448
Nucleotide Accession #NM_001270519
  1. What is the species homology for "LATS1 Antibody (OACA09411)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".

  2. How long will it take to receive "LATS1 Antibody (OACA09411)"?

    This item is available "Domestic: Antibody & Kits: 2 weeks | Proteins: 4-6 weeks | International: Antibody & Kits: 2 weeks | Proteins: 4-6 weeks".

  3. What buffer format is "LATS1 Antibody (OACA09411)" provided in?

    This item is provided in "Liquid".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "LATS1 Antibody (OACA09411)"?

    This target may also be called "h-warts;large tumor suppressor homolog 1;LATS (large tumor suppressor, Drosophila) homolog 1;LATS, large tumor suppressor, homolog 1;serine/threonine-protein kinase LATS1;WARTS;WARTS protein kinase;wts." in publications.

  5. What is the shipping cost for "LATS1 Antibody (OACA09411)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "LATS1 Antibody (OACA09411)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "LATS1 Antibody (OACA09411)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "LATS1 Antibody (OACA09411)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "LATS1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "LATS1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "LATS1"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "LATS1"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "LATS1"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "LATS1"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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