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Catalog No: OAAB16771
Size:400ul
Price: $450.00
SKU
OAAB16771
Availability: Domestic: within 1-2 week delivery | International: within 1-2 week delivery
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  • $55: Antibody & Protein in US
  • $55 + $25/Kit in US
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Datasheets/ManualsPrintable datasheet for OAAB16771
Product Info
Predicted Species ReactivityHuman, Mouse, Rat
Product FormatPurified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
ClonalityPolyclonal
IsotypeIg
HostRabbit
ApplicationWB, IHC
Additional InformationPrecautions: LATS1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
::Function: Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function
::Cellular Location: Cytoplasm, cytoskeleton, centrosome. Note=Localizes to the centrosomes throughout interphase but migrates to the mitotic apparatus, including spindle pole bodies, mitotic spindle, and midbody, during mitosis
Tissue Location: Expressed in all adult tissues examined except for lung and kidney
Reconstitution and StorageMaintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThis LATS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human LATS1.
Predicted Homology Based on Immunogen SequenceHuman; Mouse; Rat
ConcentrationApproximately 0.5mg/ml. Actual concentration varies with each lot.
Sample Type Confirmation

LATS1 is strongly supported by BioGPS gene expression data to be expressed in K562

Application InfoWB: 1:1000
IHC-P: 1:50~100
Gene SymbolLATS1
Alias Symbolswts, WARTS
NCBI Gene Id9113
Protein NameSerine/threonine-protein kinase LATS1
Description of TargetPurified Rabbit Polyclonal Antibody (Pab)
Uniprot IDO95835
Protein Accession #NP_001257448.1
Molecular Weight126870 Da
  1. What is the species homology for "LATS1 Antibody - N-terminal region (OAAB16771)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human, Mouse, Rat".

  2. How long will it take to receive "LATS1 Antibody - N-terminal region (OAAB16771)"?

    This item is available "Domestic: within 1-2 week delivery | International: within 1-2 week delivery".

  3. What buffer format is "LATS1 Antibody - N-terminal region (OAAB16771)" provided in?

    This item is provided in "Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "LATS1 Antibody - N-terminal region (OAAB16771)"?

    This target may also be called "wts, WARTS" in publications.

  5. What is the shipping cost for "LATS1 Antibody - N-terminal region (OAAB16771)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "LATS1 Antibody - N-terminal region (OAAB16771)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "LATS1 Antibody - N-terminal region (OAAB16771)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "126870 Da".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "LATS1 Antibody - N-terminal region (OAAB16771)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "LATS1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "LATS1"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "LATS1"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "LATS1"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "LATS1"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "LATS1"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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