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Catalog No: OAAF01525 (Formerly GWB-ASC895)
Size:100 ug
Price: $344.00
SKU
OAAF01525
Availability: Domestic: within 1-2 week delivery | International: 1-2 weeks
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  • $55: Antibody & Protein in US
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Datasheets/ManualsPrintable datasheet for LATS1/2 Antibody (OAAF01525)
Product Info
Predicted Species ReactivityHuman|Mouse
Product FormatLiquid
ClonalityPolyclonal
HostRabbit
ApplicationEnzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry|Immunohistochemistry-Paraffin|Western blot
Reconstitution and Storage-20°C
ImmunogenThe antiserum was produced against synthesized peptide derived from human LATS1/2.
PurificationThe antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.
SpecificityLATS1/2 antibody detects endogenous levels of total LATS1/2 protein.
FormulationRabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
DilutionThe optimal working dilution should be determined by the end user.
Application InfoIHC: 1:50~1:100; ELISA: 1:40000
ReferenceTao W., Nat. Genet. 21:177-181(1999).
Nishiyama Y., FEBS Lett. 459:159-165(1999).
The MGC Project Team, Genome Res. 14:2121-2127(2004).
Gene SymbolLATS1|LATS2
Gene Full Namelarge tumor suppressor kinase 1|large tumor suppressor kinase 2
Alias Symbolsh-warts;kinase phosphorylated during mitosis protein;KPM;large tumor suppressor homolog 1;large tumor suppressor homolog 2;LATS (large tumor suppressor, Drosophila) homolog 1;LATS (large tumor suppressor, Drosophila) homolog 2;LATS, large tumor suppressor, homolog 1;LATS, large tumor suppressor, homolog 2;serine/threonine kinase KPM;serine/threonine-protein kinase kpm;serine/threonine-protein kinase LATS1;serine/threonine-protein kinase LATS2;WARTS;WARTS protein kinase;warts-like kinase;wts.
NCBI Gene Id26524|9113
Protein NameSerine/threonine-protein kinase LATS1|Serine/threonine-protein kinase LATS2
Description of TargetNegative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function. Plays a role in mammary gland epithelial cells differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1 (PubMed:28068668).|Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities. This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ.
Uniprot IDO95835|Q9NRM7
Protein Accession #NP_055387.2
Molecular Weight126 kDa
  1. What is the species homology for "LATS1/2 Antibody (OAAF01525)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human|Mouse".

  2. How long will it take to receive "LATS1/2 Antibody (OAAF01525)"?

    This item is available "Domestic: within 1-2 week delivery | International: 1-2 weeks".

  3. What buffer format is "LATS1/2 Antibody (OAAF01525)" provided in?

    This item is provided in "Liquid".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "LATS1/2 Antibody (OAAF01525)"?

    This target may also be called "h-warts;kinase phosphorylated during mitosis protein;KPM;large tumor suppressor homolog 1;large tumor suppressor homolog 2;LATS (large tumor suppressor, Drosophila) homolog 1;LATS (large tumor suppressor, Drosophila) homolog 2;LATS, large tumor suppressor, homolog 1;LATS, large tumor suppressor, homolog 2;serine/threonine kinase KPM;serine/threonine-protein kinase kpm;serine/threonine-protein kinase LATS1;serine/threonine-protein kinase LATS2;WARTS;WARTS protein kinase;warts-like kinase;wts." in publications.

  5. What is the shipping cost for "LATS1/2 Antibody (OAAF01525)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "LATS1/2 Antibody (OAAF01525)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "LATS1/2 Antibody (OAAF01525)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "126 kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "LATS1/2 Antibody (OAAF01525)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "LATS1|LATS2"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "LATS1|LATS2"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "LATS1|LATS2"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "LATS1|LATS2"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "LATS1|LATS2"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "LATS1|LATS2"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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