LAT Antibody (Phospho-Tyr191) (OASG04199)

Catalog No: OASG04199

Size:100 uL

Product Info

• Predicted Species Reactivity: Human, Mouse, Rat
• Product Format: Liquid. 1 mg/mL in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: WB, IHC
• Reconstitution and Storage: Store at -20C. Avoid repeated freeze/thaw cycles.
• Immunogen: Synthesized peptide derived from human LAT around the phosphorylation site of Y191. Location: 160-240aa.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Concentration: 1 mg/ml
• Target Post-Translational Modification: Phospho-Tyr191
• Specificity: Phospho-LAT (Tyr191) Polyclonal Antibody detects endogenous levels of LAT protein only when phosphorylated at Y191.
• Application Info: WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000;

Target Info

• Gene Symbol: LAT
• Gene Full Name: linker for activation of T cells
• Alias Symbols: LAT1, pp36, IMD52
• NCBI Gene Id: 27040; 16797; 81511
• Description of Target: The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms.
• Uniprot ID: O43561, O54957, O70601
• Molecular Weight: 28 kDa